SCHEMBL2215142

SCHEMBL2215142

CCOC(=O)C(C#N)=Cc1cc(OC)c(OC)c(OC)c1

nearest known ligand 0.74

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 7/20 0.74
PKM P14618 1/20 0.74
HTT P42858 1/20 0.74
MAPT P10636 7/20 0.71
MEN1 O00255 3/20 0.71
KMT2A Q03164 3/20 0.71
PTP4A1 Q93096 2/20 0.62
KDM4E B2RXH2 3/20 0.57
TDP1 Q9NUW8 1/20 0.57
PDCD1 Q15116 1/20 0.56
CD274 Q9NZQ7 1/20 0.56
HPGD P15428 4/20 0.55
NPSR1 Q6W5P4 3/20 0.55
RXFP1 Q9HBX9 2/20 0.55
PTP4A3 O75365 1/20 0.55
PTP4A2 Q12974 1/20 0.55
CRHBP P24387 1/20 0.53
CRHR2 Q13324 1/20 0.53
SMN1; SMN2 Q16637 2/20 0.53
CYP3A4 P08684 1/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5618664 0.91 PTP4A1 (0.70) ALDH1A1PKMHTTMAPTMEN1
SCHEMBL5618661 0.91 PTP4A1 (0.70) ALDH1A1PKMHTTMAPTMEN1
SCHEMBL23530140 0.89 ALDH1A1 (0.75) ALDH1A1PKMHTTMAPTMEN1
SCHEMBL2211505 0.89 ALDH1A1 (0.75) ALDH1A1PKMHTTMAPTMEN1
SCHEMBL10678676 0.88 ALDH1A1 (0.73) ALDH1A1PKMHTTMAPTMEN1
SCHEMBL10678680 0.88 ALDH1A1 (0.73) ALDH1A1PKMHTTMAPTMEN1
SCHEMBL11853037 0.86 ALDH1A1 (0.70) ALDH1A1PKMHTTMAPTMEN1
SCHEMBL11853030 0.86 ALDH1A1 (0.70) ALDH1A1PKMHTTMAPTMEN1
SCHEMBL22259791 0.85 ALDH1A1 (1.00) ALDH1A1PKMHTTMAPTMEN1
SCHEMBL8364474 0.85 ALDH1A1 (1.00) ALDH1A1PKMHTTMAPTMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1952843-B1 Photostable organic sunscreen compounds with antioxidant properties and compositions obtained therefrom MERCK PATENT GMBH (DE) 2011-07-27 EP disclosed
EP-1747773-B1 Photostable organic sunscreen compositions with antioxidant properties MERCK PATENT GMBH (DE) 2010-08-04 EP disclosed
US-7687229-B2 Silver halide color photographic light-sensitive material and image forming method FUJIFILM CORPORATION (JP) 2010-03-30 US disclosed
EP-1952843-A1 Photostable organic sunscreen compounds with antioxidant properties and compositions obtained therefrom Merck Patent GmbH (DE) 2008-08-06 EP disclosed
US-20070298348-A1 Silver Halide Color Photographic Light-Sensitive Material and Image Forming Method FUJIFILM CORPORATION (JP) 2007-12-27 US disclosed
US-7189501-B2 Silver halide color photographic photosensitive material FUJI PHOTO FILM CO., LTD. (JP) 2007-03-13 US disclosed
EP-1747773-A2 Photostable organic sunscreen compositions with antioxidant properties Merck Patent GmbH (DE) 2007-01-31 EP disclosed
EP-1406582-B1 PHOTOSTABLE ORGANIC SUNSCREEN COMPOUNDS WITH ANTIOXIDANT PROPERTIES AND COMPOSITIONS OBTAINED THEREFROM MERCK PATENT GMBH (DE) 2006-10-25 EP disclosed
EP-1406582-A1 PHOTOSTABLE ORGANIC SUNSCREEN COMPOUNDS WITH ANTIOXIDANT PROPERTIES AND COMPOSITIONS OBTAINED THEREFROM MERCK PATENT GmbH (DE) 2004-04-14 EP disclosed
US-6602515-B2 Alpha-acetyl-3,5-dimethoxy-4-hydroxy cinnamate ester; dipalmitoyl-3,5- dimethoxy-4-hydroxy benzylidene malonate or amide derivatives EM INDUSTRIES 2003-08-05 US disclosed
US-20030108492-A1 PHOTO STABLE ORGANIC SUNSCREEN COMPOUNDS WITH ANTIOXIDANT PROPERTIES AND COMPOSITIONS OBTAINED THEREFROM EM INDUSTRIES 2003-06-12 US disclosed
WO-2003007906-A1 PHOTOSTABLE ORGANIC SUNSCREEN COMPOUNDS WITH ANTIOXIDANT PROPERTIES AND COMPOSITIONS OBTAINED THEREFROM MERCK PATENT GMBH (DE) 2003-01-30 WO disclosed
WO-1999036049-A1 PHOTOSTABLE UV ABSORBENT CONTAINING α-CYANO CINNAMYL MOIETY ISP INVESTMENTS INC. (US) 1999-07-22 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20030108492-A1 PHOTO STABLE ORGANIC SUNSCREEN COMPOUNDS WITH ANTIOXIDANT PROPERTIES AND COMPOSITIONS OBTAINED THEREFROM ERCC1, ERCC4, OGG1 ALDH1A1 71/4885PKM 730/4885HTT 3551/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.