Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | KRAS | P01116 | 1/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.39 |
| ▸ | PRPS1 | P60891 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | MCL1 | Q07820 | 4/20 | 0.35 |
| ▸ | CNR2 | P34972 | 4/20 | 0.35 |
| ▸ | CNR1 | P21554 | 3/20 | 0.35 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.34 |
| ▸ | CDK1 | P06493 | 1/20 | 0.34 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.34 |
| ▸ | GSK3B | P49841 | 1/20 | 0.34 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.34 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.33 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4986908 | 0.84 | SMN1; SMN2 (0.48) | ALDH1A1SMN1; SMN2LMNAMAPTHTT | |
| SCHEMBL22152483 | 0.81 | ALDH1A1 (0.44) | ALDH1A1RXFP1PRPS1SMN1; SMN2KDM4E | |
| SCHEMBL28206718 | 0.78 | KRAS (0.44) | KRASSMN1; SMN2CNR2CNR1CSNK2A1 | |
| SCHEMBL26675684 | 0.73 | CSNK2A1 (0.40) | KRASSMN1; SMN2CNR2CNR1CSNK2A1 | |
| SCHEMBL26673741 | 0.73 | CSNK2A1 (0.43) | KRASSMN1; SMN2CSNK2A1 | |
| SCHEMBL13131411 | 0.73 | HTR6 (0.40) | ALDH1A1PRPS1SMN1; SMN2MCL1CNR2 | |
| SCHEMBL22122356 | 0.71 | KRAS (0.41) | KRASSMN1; SMN2CSNK2A1TBXAS1 | |
| SCHEMBL22122430 | 0.71 | ALDH1A1 (0.43) | ALDH1A1RXFP1PRPS1CNR2CNR1 | |
| SCHEMBL29352824 | 0.70 | L3MBTL1 (0.45) | KRASSMN1; SMN2CCNB2CDK1CCNB1 | |
| SCHEMBL15777230 | 0.70 | L3MBTL1 (0.45) | KRASSMN1; SMN2CCNB2CDK1CCNB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200197391-A1 | COMPOUNDS THAT PARTICIPATE IN COOPERATIVE BINDING AND USES THEREOF | Revolution Medicines, Inc. | 2020-06-25 | — | — | US | disclosed |
| WO-2020132597-A1 | COMPOUNDS THAT PARTICIPATE IN COOPERATIVE BINDING AND USES THEREOF | Revolution Medicines, Inc. (US) | 2020-06-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200197391-A1 | COMPOUNDS THAT PARTICIPATE IN COOPERATIVE BINDING AND USES THEREOF | KRAS, NRAS, HRAS | ALDH1A1 4539/4885KRAS 1/4885RXFP1 4585/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.