Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 4/20 | 0.45 |
| ▸ | CHRNA7 | P36544 | 4/20 | 0.45 |
| ▸ | CHRNA4 | P43681 | 4/20 | 0.45 |
| ▸ | PRNP | P04156 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | PPARG | P37231 | 1/20 | 0.35 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.35 |
| ▸ | NR2E3 | Q9Y5X4 | 1/20 | 0.35 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | GLA | P06280 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22122287 | 0.80 | METAP2 (0.38) | CHRNB2CHRNA7CHRNA4NPSR1CSNK2A1 | |
| SCHEMBL11066785 | 0.79 | KIF11 (0.46) | MEN1KMT2A | |
| SCHEMBL27350234 | 0.77 | PDE9A (0.50) | CHRNB2CHRNA7CHRNA4MEN1KMT2A | |
| SCHEMBL23885530 | 0.76 | USP20 (0.51) | NPSR1MEN1KMT2AMETAP2PDPK1 | |
| SCHEMBL30053023 | 0.76 | USP20 (0.51) | NPSR1MEN1KMT2AMETAP2PDPK1 | |
| SCHEMBL4775466 | 0.75 | KIF11 (0.49) | KMT2AKDM4EGAA | |
| SCHEMBL22418045 | 0.71 | CHRNA7 (0.74) | CHRNB2CHRNA7CHRNA4PRNPCYP1A2 | |
| SCHEMBL22128207 | 0.69 | CSNK2A1 (0.37) | CHRNB2CHRNA7CHRNA4CSNK2A1METAP2 | |
| Ethane SCHEMBL29122859 | 0.67 | METAP2 (0.48) | CHRNB2CHRNA7CHRNA4ALDH1A1HPGD | |
| SCHEMBL24576237 | 0.67 | CHRNA7 (0.49) | CHRNB2CHRNA7CHRNA4PRNPCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020132597-A1 | COMPOUNDS THAT PARTICIPATE IN COOPERATIVE BINDING AND USES THEREOF | Revolution Medicines, Inc. (US) | 2020-06-25 | — | — | WO | disclosed |