Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 2/20 | 0.49 |
| ▸ | TRPA1 | O75762 | 5/20 | 0.45 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.45 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.45 |
| ▸ | DHODH | Q02127 | 1/20 | 0.38 |
| ▸ | CTSS | P25774 | 1/20 | 0.37 |
| ▸ | CTSK | P43235 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | CRHBP | P24387 | 1/20 | 0.36 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.36 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.36 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.36 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.35 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.35 |
| ▸ | HTR1A | P08908 | 1/20 | 0.34 |
| ▸ | HTR7 | P34969 | 1/20 | 0.34 |
| ▸ | HTR6 | P50406 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11066785 | 0.75 | KIF11 (0.46) | KIF11DHODHKMT2ASCN10AGSK3B | |
| SCHEMBL22152175 | 0.75 | CHRNB2 (0.45) | KDM4EGAAKMT2A | |
| SCHEMBL27350234 | 0.70 | PDE9A (0.50) | KIF11KDM4EGAAKMT2A | |
| SCHEMBL23885425 | 0.69 | NSD2 (0.57) | KIF11TRPA1SCN5ASCN9ADHODH | |
| SCHEMBL12109387 | 0.68 | IMPDH2 (0.56) | KIF11TRPA1SCN5ASCN9AKDM4E | |
| SCHEMBL28083895 | 0.67 | AR (0.46) | TRPA1SCN5ASCN9ACTSSCTSK | |
| SCHEMBL3119854 | 0.65 | KIF11 (0.64) | KIF11TRPA1SCN5ASCN9AKDM4E | |
| SCHEMBL982356 | 0.65 | KDM4E (0.53) | KDM4EHTR7HTR6GAAKMT2A | |
| SCHEMBL7256074 | 0.65 | KIF11 (0.69) | KIF11TRPA1SCN5ASCN9AKDM4E | |
| SCHEMBL7033184 | 0.64 | KIF11 (0.58) | KIF11TRPA1SCN5ASCN9ADHODH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1984332-A2 | METHODS FOR TREATING HEPATITIS C | PTC Therapeutics, Inc. (US) | 2008-10-29 | — | — | EP | disclosed |
| WO-2007084413-A2 | METHODS FOR TREATING HEPATITIS C | PTC THERAPEUTICS, INC. (US) | 2007-07-26 | — | — | WO | disclosed |