Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KAT2B | Q92831 | 1/20 | 0.40 |
| ▸ | DNM1 | Q05193 | 7/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | RAD52 | P43351 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | ASH1L | Q9NR48 | 2/20 | 0.36 |
| ▸ | TSPO | P30536 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.34 |
| ▸ | FLT1 | P17948 | 1/20 | 0.34 |
| ▸ | FLT4 | P35916 | 1/20 | 0.34 |
| ▸ | KDR | P35968 | 1/20 | 0.34 |
| ▸ | EGFR | P00533 | 1/20 | 0.33 |
| ▸ | MET | P08581 | 1/20 | 0.33 |
| ▸ | PER2 | O15055 | 1/20 | 0.33 |
| ▸ | CRY1 | Q16526 | 1/20 | 0.33 |
| ▸ | CRY2 | Q49AN0 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22156316 | 0.82 | KAT2B (0.45) | KAT2BDNM1MEN1KMT2AASH1L | |
| SCHEMBL22156262 | 0.82 | DNM1 (0.50) | KAT2BDNM1MEN1RAD52KMT2A | |
| SCHEMBL25492221 | 0.71 | DNM1 (0.57) | DNM1MEN1RAD52KMT2ATSPO | |
| SCHEMBL8182522 | 0.71 | BACE1 (0.60) | KAT2BDNM1ALDH1A1HPGDKDM4E | |
| SCHEMBL8175096 | 0.71 | BACE1 (0.60) | KAT2BDNM1ALDH1A1HPGDKDM4E | |
| SCHEMBL8175105 | 0.71 | BACE1 (0.60) | KAT2BDNM1ALDH1A1HPGDKDM4E | |
| SCHEMBL483188 | 0.70 | ALDH1A1 (0.54) | DNM1MEN1RAD52KMT2ATSPO | |
| SCHEMBL22122216 | 0.67 | KAT2B (0.68) | KAT2BALDH1A1SMN1; SMN2 | |
| SCHEMBL22122215 | 0.67 | KAT2B (0.68) | KAT2BALDH1A1SMN1; SMN2 | |
| SCHEMBL22156325 | 0.67 | SMN1; SMN2 (0.49) | KAT2BMEN1KMT2AALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020132597-A1 | COMPOUNDS THAT PARTICIPATE IN COOPERATIVE BINDING AND USES THEREOF | Revolution Medicines, Inc. (US) | 2020-06-25 | — | — | WO | disclosed |