SCHEMBL2215262

SCHEMBL2215262

COc1ccc(C(OC(C(=O)COc2ccccc2)[C@H]2O[C@@H](n3cnc4c(=O)[nH]c(N)nc43)[C@H](OCOCC(C(F)(F)F)C(F)(F)F)[C@@H]2O)(c2ccccc2)c2ccc(OC)cc2)cc1

nearest known ligand 0.43

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
TYMP P19971 2/20 0.43
HPGD P15428 1/20 0.41
TAAR1 Q96RJ0 2/20 0.40
TAS1R3 Q7RTX0 1/20 0.39
TAS1R1 Q7RTX1 1/20 0.39
HINT1 P49773 5/20 0.39
GSK3A P49840 2/20 0.37
RPS6KA3 P51812 2/20 0.37
MAPK14 Q16539 2/20 0.37
PNP P00491 1/20 0.36
KRAS P01116 2/20 0.36
FUT6 P51993 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10476437 0.95 TAAR1 (0.40) TYMPHPGDTAAR1TAS1R3TAS1R1
SCHEMBL16401489 0.90 TYMP (0.48) TYMPHPGDTAAR1TAS1R3TAS1R1
SCHEMBL2106148 0.89 TYMP (0.42) TYMPHPGDTAAR1TAS1R3TAS1R1
SCHEMBL15841440 0.88 TYMP (0.41) TYMPHPGDTAAR1TAS1R3TAS1R1
SCHEMBL2108884 0.88 TYMP (0.53) TYMPHPGDTAAR1HINT1GSK3A
SCHEMBL16401843 0.87 TYMP (0.48) TYMPHPGDTAAR1TAS1R3TAS1R1
SCHEMBL2215519 0.85 HPGD (0.35) TYMPHPGDTAAR1TAS1R3TAS1R1
SCHEMBL2107702 0.82 TYMP (0.44) TYMPHPGDTAAR1TAS1R3TAS1R1
SCHEMBL6831440 0.81 TYMP (0.48) TYMPHPGDTAAR1TAS1R3TAS1R1
SCHEMBL15048493 0.81 ADORA1 (0.42) TYMP

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2479182-B1 NOVEL PROTECTING GROUP FOR SYNTHESIZING RNA AND DERIVATIVE THEREOF CHIRALGEN LTD (JP) 2016-05-25 EP disclosed
US-8470987-B2 Protective group for synthesis of RNA and derivative CHIRALGEN, LTD. (JP) 2013-06-25 US disclosed
US-20110178284-A1 Novel protective group for synthesis of RNA and derivative CHIRALGEN, LTD. (JP) 2011-07-21 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110178284-A1 Novel protective group for synthesis of RNA and derivative RNGTT, FBL, RNASEH1 TYMP 3514/4885HPGD 1858/4885TAAR1 3177/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.