Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 | P00734 | 4/20 | 0.70 |
| ▸ | PRSS1 | P07477 | 3/20 | 0.70 |
| ▸ | PRSS2 | P07478 | 3/20 | 0.70 |
| ▸ | PRSS3 | P35030 | 3/20 | 0.70 |
| ▸ | ST14 | Q9Y5Y6 | 3/20 | 0.70 |
| ▸ | TMPRSS6 | Q8IU80 | 1/20 | 0.56 |
| ▸ | PLG | P00747 | 1/20 | 0.55 |
| ▸ | F7 | P08709 | 1/20 | 0.55 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.53 |
| ▸ | NAMPT | P43490 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | GFER | P55789 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | ULK1 | O75385 | 1/20 | 0.49 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6153470 | 0.88 | NAMPT (0.56) | F2PRSS1PRSS2PRSS3ST14 | |
| SCHEMBL8512721 | 0.83 | ST14 (1.00) | F2PRSS1PRSS2PRSS3ST14 | |
| SCHEMBL851403 | 0.83 | ST14 (1.00) | F2PRSS1PRSS2PRSS3ST14 | |
| SCHEMBL8512585 | 0.83 | ST14 (1.00) | F2PRSS1PRSS2PRSS3ST14 | |
| SCHEMBL8508917 | 0.80 | ST14 (0.93) | F2PRSS1PRSS2PRSS3ST14 | |
| SCHEMBL852298 | 0.80 | ST14 (0.93) | F2PRSS1PRSS2PRSS3ST14 | |
| SCHEMBL25845705 | 0.80 | NAMPT (0.62) | NAMPTKMT2AMEN1LMNAGAA | |
| SCHEMBL851393 | 0.80 | ST14 (0.72) | F2PRSS1PRSS2PRSS3ST14 | |
| SCHEMBL13972924 | 0.80 | KMT2A (0.62) | NAMPTKMT2AMEN1LMNAGAA | |
| SCHEMBL3211109 | 0.79 | GAA (0.72) | NAMPTKMT2AMEN1LMNAGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8088774-B2 | Anti-inflammatory and protein kinase inhibitor compositions and related methods for downregulation of detrimental cellular responses and inhibition of cell death | NORTHWESTERN UNIVERSITY (US) | 2012-01-03 | — | — | US | disclosed |
| US-8088774-B2 | Anti-inflammatory and protein kinase inhibitor compositions and related methods for downregulation of detrimental cellular responses and inhibition of cell death | NORTHWESTERN UNIVERSITY (US) | 2012-01-03 | — | — | US | disclosed |
| US-8088774-B2 | Anti-inflammatory and protein kinase inhibitor compositions and related methods for downregulation of detrimental cellular responses and inhibition of cell death | NORTHWESTERN UNIVERSITY (US) | 2012-01-03 | — | — | US | disclosed |
| US-7888357-B2 | Anti-inflammatory and protein kinase inhibitor compositions and related methods for downregulation of detrimental cellular responses and inhibition of cell death | NORTHWESTERN UNIVERSITY (US) | 2011-02-15 | — | — | US | disclosed |
| US-7888357-B2 | Anti-inflammatory and protein kinase inhibitor compositions and related methods for downregulation of detrimental cellular responses and inhibition of cell death | NORTHWESTERN UNIVERSITY (US) | 2011-02-15 | — | — | US | disclosed |
| EP-2264014-A1 | Substituted pyridazines as anti-inflammatory agents and protein kinase inhibitors | Université Louis Pasteur (FR) | 2010-12-22 | — | — | EP | disclosed |
| US-20100317665-A1 | Anti-Inflammatory And Protein Kinase Inhibitor Compositions And Related Methods For Downregulation Of Detrimental Cellular Responses And Inhibition Of Cell Death | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2010-12-16 | — | — | US | disclosed |
| US-20100317665-A1 | Anti-Inflammatory And Protein Kinase Inhibitor Compositions And Related Methods For Downregulation Of Detrimental Cellular Responses And Inhibition Of Cell Death | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2010-12-16 | — | — | US | disclosed |
| US-20100317665-A1 | Anti-Inflammatory And Protein Kinase Inhibitor Compositions And Related Methods For Downregulation Of Detrimental Cellular Responses And Inhibition Of Cell Death | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2010-12-16 | — | — | US | disclosed |
| US-20060073472-A1 | Anti-inflammatory and protein kinase inhibitor compositions and related methods for downregulation of detrimental cellular responses and inhibition of cell death | UNIVERSITE DE STRASBOURG (FR) | 2006-04-06 | — | — | US | disclosed |
| EP-1430033-A4 | ANTI-INFLAMMATORY AND PROTEIN KINASE INHIBITOR COMPOSITION AND METHOD OF USE | UNIV NORTHWESTERN (US) | 2004-12-15 | — | — | EP | disclosed |
| EP-1430033-A1 | ANTI-INFLAMMATORY AND PROTEIN KINASE INHIBITOR COMPOSITION AND METHOD OF USE | NORTHWESTERN UNIVERSITY (US) | 2004-06-23 | — | — | EP | disclosed |
| US-20030176437-A1 | Anti-inflammatory and protein kinase inhibitor compositions and related methods for downregulation of detrimental cellular responses and inhibition of cell death | NATIONAL INSTITUTES OF HEALTH - DIRECTOR DEITR | 2003-09-18 | — | — | US | disclosed |
| WO-2003018563-A1 | ANTI-INFLAMMATORY AND PROTEIN KINASE INHIBITOR COMPOSITION AND METHOD OF USE | NORTHWESTERN UNIVERSITY (US) | 2003-03-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060073472-A1 | Anti-inflammatory and protein kinase inhibitor compositions and related methods for downregulation of detrimental cellular responses and inhibition of cell death | CASP2, CASP1, DAPK2 | F2 4340/4885PRSS1 1108/4885PRSS2 2079/4885 |
| US-20030176437-A1 | Anti-inflammatory and protein kinase inhibitor compositions and related methods for downregulation of detrimental cellular responses and inhibition of cell death | CASP2, CASP1, DAPK2 | F2 4340/4885PRSS1 1108/4885PRSS2 2079/4885 |
| US-20100317665-A1 | Anti-Inflammatory And Protein Kinase Inhibitor Compositions And Related Methods For Downregulation Of Detrimental Cellular Responses And Inhibition Of Cell Death | CASP2, CASP1, DAPK2 | F2 4340/4885PRSS1 1108/4885PRSS2 2079/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.