Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | THRB | P10828 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2215612 | 0.76 | MAPT (0.37) | NPC1THRB | |
| SCHEMBL2210737 | 0.73 | — | — | |
| SCHEMBL2190441 | 0.72 | — | — | |
| SCHEMBL2188618 | 0.71 | — | — | |
| SCHEMBL4563134 | 0.69 | MAPT (0.35) | — | |
| SCHEMBL5670082 | 0.66 | ALDH1A1 (0.33) | KMT2A | |
| SCHEMBL2188149 | 0.66 | MAPT (0.37) | KMT2ANPC1 | |
| SCHEMBL2220058 | 0.66 | CACNA1G (0.30) | — | |
| SCHEMBL4543941 | 0.64 | MAPT (0.38) | MEN1KMT2ANPC1THRB | |
| SCHEMBL4543547 | 0.64 | CYP1A2 (0.32) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7973061-B2 | Anaplastic lymphoma kinase modulators and methods of use | EXELIXIS, INC. (US) | 2011-07-05 | — | — | US | claimed |