Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 7/20 | 0.70 |
| ▸ | HPGD | P15428 | 1/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.59 |
| ▸ | MEN1 | O00255 | 2/20 | 0.59 |
| ▸ | USP2 | O75604 | 2/20 | 0.59 |
| ▸ | TSHR | P16473 | 1/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.56 |
| ▸ | GAA | P10253 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1722245 | 0.87 | SMN1; SMN2 (0.57) | HRH3KMT2AMEN1USP2TSHR | |
| SCHEMBL18210853 | 0.84 | SMN1; SMN2 (0.54) | HRH3KMT2AMEN1USP2SMN1; SMN2 | |
| SCHEMBL27719954 | 0.84 | HRH3 (0.67) | HRH3HPGDKMT2AMEN1USP2 | |
| SCHEMBL1014002 | 0.83 | HPGD (0.86) | HRH3HPGDUSP2TSHRSMN1; SMN2 | |
| SCHEMBL2251044 | 0.82 | KMT2A (0.67) | HRH3KMT2AMEN1SMN1; SMN2GAA | |
| SCHEMBL13636330 | 0.82 | HRH3 (1.00) | HRH3HPGDUSP2TSHRSMN1; SMN2 | |
| SCHEMBL15265138 | 0.82 | HPGD (0.53) | HRH3HPGDKMT2AMEN1USP2 | |
| SCHEMBL3020170 | 0.81 | RECQL (0.51) | HRH3USP2SMN1; SMN2 | |
| SCHEMBL31270758 | 0.81 | GAA (0.61) | HRH3USP2SMN1; SMN2GAA | |
| SCHEMBL1481700 | 0.81 | GPR119 (0.55) | HRH3KMT2AMEN1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 37 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120283433-A1 | NOVEL PROCESSES FOR THE PREPARATION OF CYCLOPROPYL-AMIDE DERIVATIVES | MANI NEELAKANDHA S (US) | 2012-11-08 | — | — | US | disclosed |
| EP-1951699-B1 | PROCESSES FOR THE PREPARATION OF CYCLOPROPYL-AMIDE DERIVATIVES | JANSSEN PHARMACEUTICA NV (BE) | 2012-10-10 | — | — | EP | disclosed |
| US-20120029191-A1 | NOVEL PROCESSES FOR THE PREPARATION OF CYCLOPROPYL-AMIDE DERIVATIVES | MANI NEELAKANDHA S (US) | 2012-02-02 | — | — | US | disclosed |
| EP-2404911-A1 | Novel processes for the preparation of piperazinyl and diazapanyl benzamide derivatives | Janssen Pharmaceutica NV (BE) | 2012-01-11 | — | — | EP | disclosed |
| US-8063206-B2 | Processes for the preparation of cyclopropyl-amide derivatives | JANSSEN PHARMACEUTICA NV (BE) | 2011-11-22 | — | — | US | disclosed |
| US-8026242-B2 | Cyclopropyl amines as modulators of the histamine H3 receptor | JANSSEN PHARMACEUTICA NV (BE) | 2011-09-27 | — | — | US | disclosed |
| US-8026242-B2 | Cyclopropyl amines as modulators of the histamine H3 receptor | JANSSEN PHARMACEUTICA NV (BE) | 2011-09-27 | — | — | US | disclosed |
| US-8026242-B2 | Cyclopropyl amines as modulators of the histamine H3 receptor | JANSSEN PHARMACEUTICA NV (BE) | 2011-09-27 | — | — | US | disclosed |
| US-20110136797-A1 | CYCLOPROPYL AMINES AS MODULATORS OF THE HISTAMINE H3 RECEPTOR | JANSSEN PHARMACEUTICA NV (BE) | 2011-06-09 | — | — | US | disclosed |
| US-20110136797-A1 | CYCLOPROPYL AMINES AS MODULATORS OF THE HISTAMINE H3 RECEPTOR | JANSSEN PHARMACEUTICA NV (BE) | 2011-06-09 | — | — | US | disclosed |
| EP-1948607-A2 | CYCLOPROPYL AMINES AS MODULATORS OF THE HISTAMINE H3 RECEPTOR | Janssen Pharmaceutica, N.V. (BE) | 2008-07-30 | — | — | EP | disclosed |
| US-20070197508-A1 | NOVEL PROCESSES FOR THE PREPARATION OF PIPERAZINYL AND DIAZAPANYL BENZAMIDE DERIVATIVES | JANSSEN PHARMACEUTICA N.V. (BE) | 2007-08-23 | — | — | US | disclosed |
| US-20070129351-A1 | NOVEL PROCESSES FOR THE PREPARATION OF CYCLOPROPYL-AMIDE DERIVATIVES | JANSSEN PHARMACEUTICA N.V. (BE) | 2007-06-07 | — | — | US | disclosed |
| WO-2007053386-A2 | PROCESSES FOR THE PREPARATION OF CYCLOPROPYL-AMIDE DERIVATIVES | JANSSEN PHARMACEUTICA N.V. (BE) | 2007-05-10 | — | — | WO | disclosed |
| WO-2007053427-A2 | NOVEL PROCESSES FOR THE PREPARATION OF PIPERAZINYL AND DIAZAPANYL BENZAMIDE DERIVATIVES | JANSSEN PHARMACEUTICA N.V. (BE) | 2007-05-10 | — | — | WO | disclosed |
| WO-2007035425-A2 | CYCLOPROPYL AMINES AS MODULATORS OF THE HISTAMINE H3 RECEPTOR | JANSSEN PHARMACEUTICA N.V. (BE) | 2007-03-29 | — | — | WO | disclosed |
| WO-2007035425-A2 | CYCLOPROPYL AMINES AS MODULATORS OF THE HISTAMINE H3 RECEPTOR | JANSSEN PHARMACEUTICA N.V. (BE) | 2007-03-29 | — | — | WO | disclosed |
| US-20070066821-A1 | CYCLOPROPYL AMINES AS MODULATORS OF THE HISTAMINE H3 RECEPTOR | JANSSEN PHARMACEUTICA, N.V. (BE) | 2007-03-22 | — | — | US | disclosed |
| US-20070066821-A1 | CYCLOPROPYL AMINES AS MODULATORS OF THE HISTAMINE H3 RECEPTOR | JANSSEN PHARMACEUTICA, N.V. (BE) | 2007-03-22 | — | — | US | disclosed |
| US-20070066821-A1 | CYCLOPROPYL AMINES AS MODULATORS OF THE HISTAMINE H3 RECEPTOR | JANSSEN PHARMACEUTICA, N.V. (BE) | 2007-03-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070197508-A1 | NOVEL PROCESSES FOR THE PREPARATION OF PIPERAZINYL AND DIAZAPANYL BENZAMIDE DERIVATIVES | HRH2, HRH4, HRH1 | HRH3 4/4885HPGD 785/4885KMT2A 898/4885 |
| US-20070066821-A1 | CYCLOPROPYL AMINES AS MODULATORS OF THE HISTAMINE H3 RECEPTOR | HRH3, HRH4, HRH2 | HRH3 1/4885HPGD 714/4885KMT2A 540/4885 |
| US-20070129351-A1 | NOVEL PROCESSES FOR THE PREPARATION OF CYCLOPROPYL-AMIDE DERIVATIVES | HRH4, HRH2, HRH1 | HRH3 4/4885HPGD 300/4885KMT2A 1601/4885 |
| US-20120283433-A1 | NOVEL PROCESSES FOR THE PREPARATION OF CYCLOPROPYL-AMIDE DERIVATIVES | HRH4, HRH2, HRH1 | HRH3 4/4885HPGD 300/4885KMT2A 1601/4885 |
| US-20120029191-A1 | NOVEL PROCESSES FOR THE PREPARATION OF CYCLOPROPYL-AMIDE DERIVATIVES | HRH4, HRH2, HRH1 | HRH3 4/4885HPGD 300/4885KMT2A 1601/4885 |
| US-20110136797-A1 | CYCLOPROPYL AMINES AS MODULATORS OF THE HISTAMINE H3 RECEPTOR | HRH3, HRH4, HRH2 | HRH3 1/4885HPGD 714/4885KMT2A 540/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.