⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29901546 | 1.00 | — | — | |
| Iodide SCHEMBL2150737 | 0.97 | — | — | |
| Bromide SCHEMBL28499361 | 0.97 | — | — | |
| Iodide SCHEMBL14798201 | 0.87 | HRH1 (0.44) | — | |
| Iodide SCHEMBL14798203 | 0.87 | HRH1 (0.44) | — | |
| SCHEMBL28194856 | 0.80 | — | — | |
| SCHEMBL14141541 | 0.80 | HRH1 (0.42) | — | |
| SCHEMBL230753 | 0.78 | HRH1 (0.73) | — | |
| SCHEMBL41191 | 0.78 | L3MBTL1 (0.59) | — | |
| SCHEMBL29830938 | 0.78 | L3MBTL1 (0.59) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 172 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117599857-A | Porous organic metal iridium polymer in aqueous solution for catalyzing CO 2 Method for preparing formic acid by hydrogenation | 南京大学 | 2024-02-27 | — | — | CN | claimed |
| CN-112573998-B | Refining method of tertiary butanol | 万华化学集团股份有限公司（CN） | 2023-01-13 | — | — | CN | claimed |
| CN-114361590-A | Lithium ion battery electrolyte additive, electrolyte and lithium ion battery | 松山湖材料实验室 | 2022-04-15 | — | — | CN | claimed |
| CN-112573998-A | Refining method of tertiary butanol | 万华化学集团股份有限公司 | 2021-03-30 | — | — | CN | claimed |
| CN-110498766-A | Fluazinam haptens, artificial antigen and antibody and its preparation method and application | BEIJING KWINBON BIOTECH CO LTD | 2019-11-26 | — | — | CN | claimed |
| CN-109627211-A | The method that one kettle way prepares ZEN 90160 | 合肥利夫生物科技有限公司 | 2019-04-16 | — | — | CN | claimed |
| CN-108727618-A | A kind of polyethylene film and preparation method thereof with fluoro-containing pesticide adhesive coating | 四川羽玺科技有限公司 | 2018-11-02 | — | — | CN | claimed |
| US-10106508-B2 | Quinazoline heterocyclic compound as EGFR kinase inhibitor and preparation and application thereof | BEIJING SCITECH-MQ PHARMACEUTICALS LIMITED (CN) | 2018-10-23 | — | — | US | claimed |
| US-20170355683-A1 | QUINAZOLINE HETEROCYCLIC COMPOUND AS EGFR KINASE INHIBITOR AND PREPARATION AND APPLICATION THEREOF | BEIJING SCITECH-MQ PHARMACEUTICALS LIMITED (CN) | 2017-12-14 | — | — | US | claimed |
| EP-3246328-A1 | QUINAZOLINE HETEROCYCLIC COMPOUND AS EGFR KINASE INHIBITOR, AND PREPARATION AND APPLICATION THEREOF | Beijing Scitech-MQ Pharmaceuticals Limited (CN) | 2017-11-22 | — | — | EP | claimed |
| CN-106866510-A | A kind of preparation method of the trifluoromethyl pyridine of 2 chlorine of high-purity 5 | 内蒙古佳瑞米精细化工有限公司 | 2017-06-20 | — | — | CN | claimed |
| CN-106748981-A | A kind of residual recoverying and utilizing method of fluoromethyl pyridine reactor | 大连九信精细化工有限公司 | 2017-05-31 | — | — | CN | claimed |
| CN-104321310-B | Process for preparing 3-substituted-6-trifluoromethylpyridines and process for using 6-trichloromethyl halopyridines | 陶氏益农公司 | 2017-02-22 | — | — | CN | claimed |
| CN-106279006-A | A kind of preparation method of the high purity extractive cover grass energy of environmental protection | 江苏威耳化工有限公司 | 2017-01-04 | — | — | CN | claimed |
| CN-105859791-A | Iridium complexes and preparation method thereof, and electroluminescent device using iridium complexes | 瑞声光电科技(常州)有限公司 | 2016-08-17 | — | — | CN | claimed |
| EP-0495939-A4 | SEQUENTIAL C-TERMINAL DEGRADATION OF PEPTIDES AND PROTEINS | — | 1992-11-25 | — | — | EP | claimed |
| EP-0495939-A1 | SEQUENTIAL C-TERMINAL DEGRADATION OF PEPTIDES AND PROTEINS. | HOPE CITY (US) | 1992-07-29 | — | — | EP | claimed |
| WO-1992003737-A1 | SEQUENTIAL C-TERMINAL DEGRADATION OF PEPTIDES AND PROTEINS | CITY OF HOPE (US) | 1992-03-05 | — | — | WO | claimed |
| EP-0063872-B1 | PROCESS FOR THE PREPARATION OF FLUOROMETHYL PYRIDINES AND CERTAIN NOVEL PRODUCTS OBTAINED THEREFROM | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1985-07-17 | — | — | EP | claimed |
| US-12054472-B2 | 1,2,4-triazine-4-amine derivatives | NXERA PHARMA UK LIMITED (GB) | 2024-08-06 | — | — | US | disclosed |
| CN-118164961-A | 4-Methylsulfonyl substituted piperidine urea compounds for the treatment of Dilated Cardiomyopathy (DCM) | 迈奥卡迪亚公司 | 2024-06-11 | — | — | CN | disclosed |
| US-11981929-B2 | Use of small molecules to enhance MAFA expression in pancreatic endocrine cells | JANSSEN BIOTECH, INC. (US) | 2024-05-14 | — | — | US | disclosed |
| CN-111393414-B | 4-Methylsulfonyl substituted piperidine urea compounds for the treatment of Dilated Cardiomyopathy (DCM) | 迈奥卡迪亚公司 | 2024-05-07 | — | — | CN | disclosed |
| US-11939427-B2 | Process for preparing polycarbonate and catalytic system used | ENI S.P.A. (IT) | 2024-03-26 | — | — | US | disclosed |
| WO-2023171697-A1 | PRODUCTION METHOD FOR FLUORINE-CONTAINING COMPOUND | ＡＧＣ株式会社 | 2023-09-14 | — | — | WO | disclosed |
| US-20230021177-A1 | 1,2,4-TRIAZINE-4-AMINE DERIVATIVES | NXERA PHARMA UK LIMITED (GB) | 2023-01-19 | — | — | US | disclosed |
| CN-112573998-B | Refining method of tertiary butanol | 万华化学集团股份有限公司（CN） | 2023-01-13 | — | — | CN | disclosed |
| EP-4107154-A1 | HETEROARYL HETEROCYCLIC COMPOUNDS AND USES THEREOF | Hutchison Medipharma Limited (CN) | 2022-12-28 | — | — | EP | disclosed |
| EP-3710510-B1 | PROCESS FOR PREPARING POLYCARBONATE AND CATALYTIC SYSTEM USED | ENI SPA (IT) | 2021-09-22 | — | — | EP | disclosed |
| US-10988455-B2 | 1,2,4-triazine-4-amine derivatives | HEPTARES THERAPEUTICS LIMITED (GB) | 2021-04-27 | — | — | US | disclosed |
| CN-112573998-A | Refining method of tertiary butanol | 万华化学集团股份有限公司 | 2021-03-30 | — | — | CN | disclosed |
| US-20200369828-A1 | PROCESS FOR PREPARING POLYCARBONTE AND CATALYTIC SYSTEM USED | ENI S.P.A. (IT) | 2020-11-26 | — | — | US | disclosed |
| EP-3710510-A1 | PROCESS FOR PREPARING POLYCARBONATE AND CATALYTIC SYSTEM USED | ENI S.p.A. (IT) | 2020-09-23 | — | — | EP | disclosed |
| CN-111393414-A | 4-methylsulfonyl substituted piperidine urea compounds for the treatment of Dilated Cardiomyopathy (DCM) | 迈奥卡迪亚公司 | 2020-07-10 | — | — | CN | disclosed |
| US-20200121677-A1 | SUBSTITUTED 6,7-DIHYDROPYRAZOLO[1,5-a]PYRAZINES AS NEGATIVE ALLOSTERIC MODULATORS OF MGLUR2 RECEPTORS | JANSSEN PHARMACEUTICA NV (US) | 2020-04-23 | — | — | US | disclosed |
| CN-107428719-B | 4-methylsulfonyl substituted piperidine urea compounds for the treatment of Dilated Cardiomyopathy (DCM) | 迈奥卡迪亚公司 | 2020-03-27 | — | — | CN | disclosed |
| WO-2020037109-A1 | PROCESSES FOR FLUORINATION | DOW AGROSCIENCES LLC (US) | 2020-02-20 | — | — | WO | disclosed |
| EP-3611164-A1 | PYRIDONE COMPOUND, AND AGRICULTURAL AND HORTICULTURAL FUNGICIDE HAVING THIS AS ACTIVE COMPONENT | Mitsui Chemicals Agro, Inc. (JP) | 2020-02-19 | — | — | EP | disclosed |
| WO-2020017569-A1 | T-TYPE CALCIUM CHANNEL BLOCKER | 日本ケミファ株式会社 | 2020-01-23 | — | — | WO | disclosed |
| CN-110475764-A | The purification process of trifluoromethyl pyridine class | ISHIHARA SANGYO KAISHA | 2019-11-19 | — | — | CN | disclosed |
| CN-110467567-A | A kind of preparation method of ZEN 90160 | CAC NANTONG CHEMICAL CO LTD | 2019-11-19 | — | — | CN | disclosed |
| CN-110003096-A | A method of preparing 2- chloro-5-trifluoromethylpyridine | 浙江省化工研究院有限公司 | 2019-07-12 | — | — | CN | disclosed |
| CN-110003098-A | A kind of method that the gas phase catalysis chlorination of 3- trifluoromethyl pyridine prepares 2- chloro-5-trifluoromethylpyridine | 浙江省化工研究院有限公司 | 2019-07-12 | — | — | CN | disclosed |
| CN-106220555-B | A method of preparing 2- aminomethyl -3- chloro-5-trifluoromethylpyridine | 天津市均凯化工科技有限公司 | 2019-06-21 | — | — | CN | disclosed |
| CN-109879802-A | A method of preparing bis- chloro-5-trifluoromethylpyridine of 2,3- with high selectivity | 浙江省化工研究院有限公司 | 2019-06-14 | — | — | CN | disclosed |
| CN-107056689-B | A kind of preparation method of 3- chlorine-4-iodine -2- trifluoromethyl pyridine | 无锡捷化医药科技有限公司 | 2019-05-07 | — | — | CN | disclosed |
| CN-109593061-A | Androgen receptor antagonists, preparation method and its application | 昆明积大制药股份有限公司 | 2019-04-09 | — | — | CN | disclosed |
| CN-106349159-B | A kind of preparation method of the chloro- 2- cyano -5- trifluoromethyl pyridine of 3- | 山东省联合农药工业有限公司 | 2019-03-22 | — | — | CN | disclosed |
| CN-109476600-A | Pyrithione, pharmaceutical compositions thereof and therapeutic use thereof for treating proliferative, inflammatory, neurodegenerative or immune-mediated diseases | 拜欧赛里克斯公司 | 2019-03-15 | — | — | CN | disclosed |
| US-20190055257-A1 | SUBSTITUTED 6,7-DIHYDROPYRAZOLO[1,5-a]PYRAZINES AS NEGATIVE ALLOSTERIC MODULATORS OF MGLUR2 RECEPTORS | JANSSEN PHARMACEUTICA NV (BE) | 2019-02-21 | — | — | US | disclosed |
| US-20190047978-A1 | 1,2,4-TRIAZINE-4-AMINE DERIVATIVES | NXERA PHARMA UK LIMITED (GB) | 2019-02-14 | — | — | US | disclosed |
| CN-104447519-B | A method of preparing the bromo- 6- trifluoromethyl pyridine of 3- substitution -2- | 成都安斯利生物医药有限公司 | 2019-01-22 | — | — | CN | disclosed |
| CN-109232400-A | The method that one kind being continuously synthesizing to 2,3-, bis- chloro-5-trifluoromethylpyridine | 中触媒新材料股份有限公司 | 2019-01-18 | — | — | CN | disclosed |
| WO-2019000236-A1 | 3-(1H-PYRAZOL-4-YL)PYRIDINE ALLOSTERIC MODULATORS OF M4 MUSCARINIC ACETYLCHOLINE RECEPTOR | MERCK SHARP & DOHME CORP. (US) | 2019-01-03 | — | — | WO | disclosed |
| CN-109053553-A | The synthetic method of insecticide sulfoxaflor intermediate 3- [1- (methyl mercapto) ethyl] -6 (trifluoromethyl) pyridines | 山东省农药科学研究院 | 2018-12-21 | — | — | CN | disclosed |
| CN-108997203-A | A kind of process for effectively purifying of bis- chloro-5-trifluoromethylpyridine of 2,3- | 江苏扬农化工集团有限公司 | 2018-12-14 | — | — | CN | disclosed |
| CN-108929264-A | A kind of preparation method of fluazinam | 岳晟 | 2018-12-04 | — | — | CN | disclosed |
| US-10112923-B2 | 1,2,4-triazine-4-amine derivatives | HEPTARES THERAPEUTICS LIMITED (GB) | 2018-10-30 | — | — | US | disclosed |
| US-10106508-B2 | Quinazoline heterocyclic compound as EGFR kinase inhibitor and preparation and application thereof | BEIJING SCITECH-MQ PHARMACEUTICALS LIMITED (CN) | 2018-10-23 | — | — | US | disclosed |
| CN-108530352-A | A kind of synthetic method of 2,6- dichlor-4-trifluoromethyls niacinamide | 福州兴创云达新材料科技有限公司 | 2018-09-14 | — | — | CN | disclosed |
| CN-108431007-A | PYRAZOLOPYRIMIDINE DERIVATIVES AS BTK INHIBITORS FOR THE TREATMENT OF CANCER | 洛克索肿瘤学股份有限公司 | 2018-08-21 | — | — | CN | disclosed |
| CN-108368084-A | Biaryl kinase inhibitors | 百时美施贵宝公司 | 2018-08-03 | — | — | CN | disclosed |
| CN-105541706-B | A kind of chloro- 2- diazanyls -5- trifluoromethyl pyridines derivative of 3- and its preparation and application | 浙江工业大学 | 2018-07-06 | — | — | CN | disclosed |
| US-10005786-B2 | Substituted 6,7-dihydropyrazolo[1,5-a]pyrazines as negative allosteric modulators of MGLUR2 receptors | JANSSEN PHARMACEUTICA NV (BE) | 2018-06-26 | — | — | US | disclosed |
| CN-107954924-A | A kind of preparation method of the fluoro- 3- chloro-5-trifluoromethylpyridines of 2- | 内蒙古佳瑞米精细化工有限公司 | 2018-04-24 | — | — | CN | disclosed |
| CN-106061974-B | Maleimide derivatives as the conditioning agent of WNT approach | 新加坡科技研究局 | 2018-04-20 | — | — | CN | disclosed |
| EP-2802326-B1 | HEPATITIS C VIRUS INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2018-04-18 | — | — | EP | disclosed |
| CN-107814759-A | The preparation method of fluopicolide | 常州沃腾化工科技有限公司 | 2018-03-20 | — | — | CN | disclosed |
| CN-106414389-B | The method that the ketone of 4 alkoxy, 1,1,1 trifluoro fourth, 3 alkene 2 is prepared from 1,1,1 trifluoroacetones | 隆萨有限公司 | 2018-03-02 | — | — | CN | disclosed |
| US-20170355683-A1 | QUINAZOLINE HETEROCYCLIC COMPOUND AS EGFR KINASE INHIBITOR AND PREPARATION AND APPLICATION THEREOF | BEIJING SCITECH-MQ PHARMACEUTICALS LIMITED (CN) | 2017-12-14 | — | — | US | disclosed |
| WO-2017214549-A1 | BTEX METABOLITES DERIVATIZATION KIT AND COMPOSITION | BOARD OF REGENTS THE UNIVERSITY OF TEXAS SYSTEM (US) | 2017-12-14 | — | — | WO | disclosed |
| EP-3246328-A1 | QUINAZOLINE HETEROCYCLIC COMPOUND AS EGFR KINASE INHIBITOR, AND PREPARATION AND APPLICATION THEREOF | Beijing Scitech-MQ Pharmaceuticals Limited (CN) | 2017-11-22 | — | — | EP | disclosed |
| CN-105013517-B | A kind of catalyst for being used for the preparation of 3 trifluoromethyl pyridines | 浙江化工院科技有限公司 | 2017-11-10 | — | — | CN | disclosed |
| CN-107286087-A | A kind of synthetic method of the trifluoromethyl pyridine of 2 cyano group, 3 chlorine 5 | 内蒙古佳瑞米精细化工有限公司 | 2017-10-24 | — | — | CN | disclosed |
| US-20170291888-A1 | 1,2,4-TRIAZINE-4-AMINE DERIVATIVES | NXERA PHARMA UK LIMITED (GB) | 2017-10-12 | — | — | US | disclosed |
| CN-107151229-A | A kind of method for producing the trifluoromethyl pyridine of 2 chlorine 4 | 内蒙古佳瑞米精细化工有限公司 | 2017-09-12 | — | — | CN | disclosed |
| US-20170217972-A1 | 6,7-DIHYDROPYRAZOLO[1,5-a]PYRAZIN-4(5H)-ONE COMPOUNDS AND THEIR USE AS NEGATIVE ALLOSTERIC MODULATORS OF MGLUR2 RECEPTORS | JANSSEN PHARMACEUTICA NV (BE) | 2017-08-03 | — | — | US | disclosed |
| CN-206308011-U | A kind of retracting device of hydrogen fluoride | 内蒙古佳瑞米精细化工有限公司 | 2017-07-07 | — | — | CN | disclosed |
| WO-2017107089-A1 | 3- (1H-PYRAZOL-4-YL) PYRIDINEALLOSTERIC MODULATORS OF THE M4 MUSCARINIC ACETYLCHOLINE RECEPTOR | MERCK SHARP & DOHME CORP. (US) | 2017-06-29 | — | — | WO | disclosed |
| CN-106866518-A | A kind of synthetic method of the trifluoromethyl pyridine of 2 amino, 3 chlorine 5 | 内蒙古佳瑞米精细化工有限公司 | 2017-06-20 | — | — | CN | disclosed |
| CN-106866512-A | A kind of preparation method of the trifluoromethyl pyridine of 2 hydroxyl 6 | 常州沃腾化工科技有限公司 | 2017-06-20 | — | — | CN | disclosed |
| CN-106748981-A | A kind of residual recoverying and utilizing method of fluoromethyl pyridine reactor | 大连九信精细化工有限公司 | 2017-05-31 | — | — | CN | disclosed |
| CN-106748981-A | A kind of residual recoverying and utilizing method of fluoromethyl pyridine reactor | 大连九信精细化工有限公司 | 2017-05-31 | — | — | CN | disclosed |
| CN-106748981-A | A kind of residual recoverying and utilizing method of fluoromethyl pyridine reactor | 大连九信精细化工有限公司 | 2017-05-31 | — | — | CN | disclosed |
| EP-3004107-B1 | 6,7-DIHYDROPYRAZOLO[1,5-A]PYRAZIN-4(5H)-ONE COMPOUNDS AND THEIR USE AS NEGATIVE ALLOSTERIC MODULATORS OF MGLUR2 RECEPTORS | JANSSEN PHARMACEUTICA NV (BE) | 2017-05-10 | — | — | EP | disclosed |
| CN-106632492-A | Platinum complex | 瑞声光电科技(常州)有限公司 | 2017-05-10 | — | — | CN | disclosed |
| CN-103607895-B | Cyclohexanone compounds and herbicides comprising same | 住友化学株式会社 | 2017-04-12 | — | — | CN | disclosed |
| EP-3143127-A1 | USE OF SMALL MOLECULES TO ENHANCE MAFA EXPRESSION IN PANCREATIC ENDOCRINE CELLS | Janssen Biotech, Inc. (US) | 2017-03-22 | — | — | EP | disclosed |
| CN-106414389-A | Method for preparation of 4-alkoxy-1,1,1-trifluorobut-3-en-2- ones from 1,1,1-trifluoroacetone | 隆萨有限公司 | 2017-02-15 | — | — | CN | disclosed |
| CN-106316933-A | Continuous preparation method for 2-fluoro-6-trifluoromethyl pyridine | 大连九信精细化工有限公司 | 2017-01-11 | — | — | CN | disclosed |
| CN-106220555-A | A kind of method preparing 2 aminomethyl 3 chlorine 5 trifluoromethyl pyridines | 衡水均凯化工有限公司 | 2016-12-14 | — | — | CN | disclosed |
| CN-106117131-A | A kind of method preparing 2 amino 3 chlorine 5 trifluoromethyl pyridines | 天津市均凯化工科技有限公司 | 2016-11-16 | — | — | CN | disclosed |
| CN-106061974-A | Maleimide derivatives as modulators of WNT pathway | 新加坡科技研究局 | 2016-10-26 | — | — | CN | disclosed |
| WO-2016162325-A1 | SUBSTITUTED 3,4-DIHYDROPYRROLO[1,2-A]PYRAZIN-1 (2H)-ONE DERIVATIVES AS KINASE INHIBITORS | ASTRAZENECA AB (SE) | 2016-10-13 | — | — | WO | disclosed |
| CN-105884679-A | Method for preparing 5, 6-dichloro-3-hydroxymethylpyridine-2-phenol from DCTF rectification and short-steaming residues | 江苏天宇检测技术有限公司 | 2016-08-24 | — | — | CN | disclosed |
| CN-105859789-A | Iridium complex and preparation method thereof, electroluminescent device using iridium complex | 瑞声光电科技(常州)有限公司 | 2016-08-17 | — | — | CN | disclosed |
| CN-105859790-A | Iridium complex, preparation method thereof and electroluminescent device applying iridium complex | 瑞声光电科技(常州)有限公司 | 2016-08-17 | — | — | CN | disclosed |
| US-20160175314-A1 | 1,2,4-TRIAZINE-4-AMINE DERIVATIVES | HEPTARES THERAPEUTICS LIMITED (GB) | 2016-06-23 | — | — | US | disclosed |
| CN-103917528-B | PYRIMIDINE PDE10 INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2016-04-20 | — | — | CN | disclosed |
| CN-105498052-A | Apparatus and method for aerosol delivery to the lungs or other locations of the body | PENN-CENTURY INC | 2016-04-20 | — | — | CN | disclosed |
| EP-2531492-B1 | 1,2,4-TRIAZINE-4-AMINE DERIVATIVES | HEPTARES THERAPEUTICS LTD (GB) | 2016-04-13 | — | — | EP | disclosed |
| US-9249130-B2 | 1,2,4-triazine-4-amine derivatives | HEPTARES THERAPEUTICS LIMITED (GB) | 2016-02-02 | — | — | US | disclosed |
| CN-102883765-B | Device and method for delivering aerosol to the lungs or other locations of the body | Penn-Century, Inc. (US) | 2015-12-09 | — | — | CN | disclosed |
| WO-2015175307-A1 | USE OF SMALL MOLECULES TO ENHANCE MAFA EXPRESSION IN PANCREATIC ENDOCRINE CELLS | JANSSEN BIOTECH, INC. (US) | 2015-11-19 | — | — | WO | disclosed |
| WO-2015151116-A2 | PROCESS FOR PRODUCING 2-FLUORO-6-(TRIFLUOROMETHYL)PYRIDINE COMPOUNDS | JUBILANT LIFE SCIENCES LIMITED (IN) | 2015-10-08 | — | — | WO | disclosed |
| CN-102993084-B | Alkynyl derivatives as modulators of metabotropic glutamate receptors | ADDEX PHARMACEUTICALS SA | 2015-05-20 | — | — | CN | disclosed |
| CN-104370804-A | Substituted methylamine compound preparation method | NIPPON SODA CO | 2015-02-25 | — | — | CN | disclosed |
| US-20150005276-A1 | 1,2,4-TRIAZINE-4-AMINE DERIVATIVES | NXERA PHARMA UK LIMITED (GB) | 2015-01-01 | — | — | US | disclosed |
| EP-2817308-A1 | PYRIDOPYRIMIDINONE INHIBITORS OF KINASES | AbbVie Inc. (US) | 2014-12-31 | — | — | EP | disclosed |
| CN-102822150-B | 1,2, 4-triazin-4-amine derivatives | HEPTARES THERAPEUTICS LTD | 2014-12-03 | — | — | CN | disclosed |
| EP-2470012-B1 | NOVEL PYRROLIDINE DERIVED BETA 3 ADRENERGIC RECEPTOR AGONISTS | MERCK SHARP & DOHME (US) | 2014-11-05 | — | — | EP | disclosed |
| US-8835467-B2 | SIR2 regulation | ALBERT EINSTEIN COLLEGE OF MEDICINE OF YESHIVA UNIVERSITY (US) | 2014-09-16 | — | — | US | disclosed |
| US-8809525-B2 | 1,2,4-triazine-4-amine derivatives | HEPTARES THERAPEUTICS LIMITED (GB) | 2014-08-19 | — | — | US | disclosed |
| CN-103917528-A | Pyrimidine PDE10 inhibitors | MERCK SHARP & DOHME | 2014-07-09 | — | — | CN | disclosed |
| US-20130231351-A1 | SIR2 REGULATION | ALBERT EINSTEIN COLLEGE OF MEDICINE OF YESHIVA UNIVERSITY (US) | 2013-09-05 | — | — | US | disclosed |
| WO-2013126656-A1 | PYRIDOPYRIMIDINONE INHIBITORS OF KINASES | ABBVIE INC. (US) | 2013-08-29 | — | — | WO | disclosed |
| CN-1989122-B | Novel cyclopenta [ b ] benzofuran derivatives and uses thereof | INTERMED DISCOVERY GMBH | 2013-07-24 | — | — | CN | disclosed |
| US-8383653-B2 | SIR2 regulation | ALBERT EINSTEIN COLLEGE OF MEDICINE OF YESHIVA UNIVERSITY (US) | 2013-02-26 | — | — | US | disclosed |
| US-20130029963-A1 | 1,2,4-TRIAZINE-4-AMINE DERIVATIVES | HEPTARES THERAPEUTICS LIMITED (GB) | 2013-01-31 | — | — | US | disclosed |
| EP-2531492-A1 | 1,2,4-TRIAZINE-4-AMINE DERIVATIVES | Heptares Therapeutics Limited (GB) | 2012-12-12 | — | — | EP | disclosed |
| CN-102822150-A | 1,2, 4-triazin-4-amine derivatives | HEPTARES THERAPEUTICS LTD | 2012-12-12 | — | — | CN | disclosed |
| WO-2011095625-A1 | 1,2,4-TRIAZINE-4-AMINE DERIVATIVES | HEPTARES THERAPEUTICS LIMITED (GB) | 2011-08-11 | — | — | WO | disclosed |
| US-20110178102-A1 | SIR2 REGULATION | ALBERT EINSTEIN COLLEGE OF MEDICINE OF YESHIVA UNIVERSITY (US) | 2011-07-21 | — | — | US | disclosed |
| CN-101195672-B | Method for producing olefin-copolymerization catalyst and method for producing olefin-copolymers | SUMITOMO CHEMICAL CO | 2011-07-06 | — | — | CN | disclosed |
| WO-2011025774-A1 | NOVEL PYRROLIDINE DERIVED BETA 3 ADRENERGIC RECEPTOR AGONISTS | MERCK SHARP & DOHME CORP. (US) | 2011-03-03 | — | — | WO | disclosed |
| US-20100317706-A1 | HNF4alpha MODULATORS AND METHODS OF USE | BUMHAM INSTITUTE FOR MEDICAL RESEARCH (US) | 2010-12-16 | — | — | US | disclosed |
| EP-1458392-B9 | ACRIDONES AS INHIBITORS OF IMPDH ENZYME | BRISTOL MYERS SQUIBB CO (US) | 2010-07-28 | — | — | EP | disclosed |
| WO-2010063487-A1 | PYRAZOLOPYRIMIDINES, A PROCESS FOR THEIR PREPARATION AND THEIR USE AS MEDICINE | MERZ PHARMA GMBH & CO. KGAA (DE) | 2010-06-10 | — | — | WO | disclosed |
| US-7732540-B2 | Process for producing olefin copolymerization catalyst and process for producing olefin copolymer | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2010-06-08 | — | — | US | disclosed |
| US-20100036119-A1 | FLUORINATING REAGENTS AND THEIR PREPARATION | LANXESS DEUTSCHLAND GMBH (DE) | 2010-02-11 | — | — | US | disclosed |
| EP-1458392-B1 | ACRIDONES AS INHIBITORS OF IMPDH ENZYME | BRISTOL MYERS SQUIBB CO (US) | 2009-09-02 | — | — | EP | disclosed |
| US-20090018012-A1 | Process for Producing Olefin Copolymerization Catalyst and Process for Producing Olefin Copolymer | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2009-01-15 | — | — | US | disclosed |
| WO-2008119563-A2 | METHOD FOR PRODUCING EPOTHILONE DERIVATIVES BY MEANS OF SELECTIVE CATALYTIC EPOXIDATION | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2008-10-09 | — | — | WO | disclosed |
| US-20080242868-A1 | PROCESS FOR PREPARING EPOTHILONE DERIVATIVES BY SELECTIVE CATALYTIC EPOXIDATION | BAYER SCHERING PHARMA AG (DE) | 2008-10-02 | — | — | US | disclosed |
| CN-101195672-A | Method for producing olefin-copolymerization catalyst and method for producing olefin-copolymers | SUMITOMO CHEMICAL CO (JP) | 2008-06-11 | — | — | CN | disclosed |
| US-7312209-B2 | Acridone inhibitors of IMPDH enzyme | BRISTOL-MYERS SQUIBB COMPANY (US) | 2007-12-25 | — | — | US | disclosed |
| CN-1989122-A | Novel cyclopenta [ b ] benzofuran derivatives and uses thereof | BAYER HEALTHCARE AG (DE) | 2007-06-27 | — | — | CN | disclosed |
| EP-1765795-A2 | ALKYNYL DERIVATIVES AS MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS | Addex Pharmaceuticals SA (CH) | 2007-03-28 | — | — | EP | disclosed |
| EP-1648459-A1 | SIR2 REGULATION | ALBERT EINSTEIN COLLEGE OF MEDICINE OF YESHIVA UNIVERSITY (US) | 2006-04-26 | — | — | EP | disclosed |
| WO-2005123703-A2 | ALKYNYL DERIVATIVES AS MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS | ADDEX PHARMACEUTICALS SA (CH) | 2005-12-29 | — | — | WO | disclosed |
| EP-1458392-A4 | ACRIDONE INHIBITORS OF IMPDH ENZYME | BRISTOL MYERS SQUIBB CO (US) | 2005-06-08 | — | — | EP | disclosed |
| WO-2005016342-A1 | SIR2 REGULATION | ALBERT EINSTEIN COLLEGE OF MEDICINE OF YESHIVA UNIVERSITY (US) | 2005-02-24 | — | — | WO | disclosed |
| EP-1458392-A2 | ACRIDONE INHIBITORS OF IMPDH ENZYME | Bristol-Myers Squibb Company (US) | 2004-09-22 | — | — | EP | disclosed |
| CN-1500086-A | Aminopiperidine derivatives | 霍夫曼-拉罗奇有限公司 | 2004-05-26 | — | — | CN | disclosed |
| US-6737429-B2 | TREATMENT OF HIV MEDIATED DISEASES. | HOFFMANN-LA ROCHE INC. | 2004-05-18 | — | — | US | disclosed |
| EP-1417202-A2 | AMINOPIPERIDINE DERIVATIVES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | F. HOFFMANN-LA ROCHE AG (CH) | 2004-05-12 | — | — | EP | disclosed |
| US-20040053955-A1 | Acridone inhibitors of IMPDH enzyme | BRISTOL-MYERS SQUIBB COMPANY | 2004-03-18 | — | — | US | disclosed |
| US-20040038331-A1 | Solid phase synthesis of biomolecule conjugates | BECKMAN COULTER, INC. | 2004-02-26 | — | — | US | disclosed |
| CN-1440385-A | Pyrrole derivatives for the treatment of AIDS | HOFFMANN LA ROCHE (CH) | 2003-09-03 | — | — | CN | disclosed |
| WO-2003059269-A2 | ACRIDONE INHIBITORS OF IMPDH ENZYME | BRISTOL-MYERS SQUIBB COMPANY (US) | 2003-07-24 | — | — | WO | disclosed |
| EP-1301481-A1 | PYRROLE DERIVATIVES FOR TREATING AIDS | F. HOFFMANN-LA ROCHE AG (CH) | 2003-04-16 | — | — | EP | disclosed |
| US-20030069276-A1 | Amino piperidine derivatives | F.HOFFMANN-LA ROCHE AG (CH) | 2003-04-10 | — | — | US | disclosed |
| WO-2002079186-A2 | AMINOPIPERIDINE DERIVATIVES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | F. HOFFMANN-LA ROCHE AG (CH) | 2002-10-10 | — | — | WO | disclosed |
| US-20020032221-A1 | Pyrrole derivatives | ROCHE PRODUCTS LIMITED (GB) | 2002-03-14 | — | — | US | disclosed |
| WO-2002002524-A1 | PYRROLE DERIVATIVES FOR TREATING AIDS | F. HOFFMANN-LA ROCHE AG (CH) | 2002-01-10 | — | — | WO | disclosed |
| US-6110987-A | CURED PRODUCTS HAVING AN EXCELLENT APPEARANCE WITHOUT COLORING CAUSED BY POLYMERIZATION INITIATOR | SHOWA DENKO K.K. (JP) | 2000-08-29 | — | — | US | disclosed |
| EP-0984935-A1 | METHOD FOR PRODUCING SUBSTITUTED THIOPYRIDINES | BASF AKTIENGESELLSCHAFT (DE) | 2000-03-15 | — | — | EP | disclosed |
| WO-1998054139-A1 | METHOD FOR PRODUCING SUBSTITUTED THIOPYRIDINES | BASF AKTIENGESELLSCHAFT (DE) | 1998-12-03 | — | — | WO | disclosed |
| EP-0843662-A1 | SUBSTITUTED 2-PHENYLPYRIDINES USEFUL AS HERBICIDES | BASF AKTIENGESELLSCHAFT (DE) | 1998-05-27 | — | — | EP | disclosed |
| WO-1998000750-A1 | PROCESS FOR PRODUCING LIQUID CRYSTAL ALIGNMENT LAYER AND LIQUID CRYSTAL DISPLAY DEVICE WITH THE USE OF THE SAME | HOECHST RESEARCH & TECHNOLOGY DEUTSCHLAND GMBH & CO. KG (DE) | 1998-01-08 | — | — | WO | disclosed |
| WO-1997006143-A1 | SUBSTITUTED 2-PHENYLPYRIDINES USEFUL AS HERBICIDES | BASF AKTIENGESELLSCHAFT (DE) | 1997-02-20 | — | — | WO | disclosed |
| US-5142055-A | Dehydrofluorinating reduced fluoroalkyl pyridine compound | MONSANTO COMPANY (US) | 1992-08-25 | — | — | US | disclosed |
| US-4978384-A | HERBICIDES | MONSANTO COMPANY (US) | 1990-12-18 | — | — | US | disclosed |
| EP-0206951-B1 | PROCESS FOR THE PERFLUOROALKYLATION OF AROMATIC DERIVATIVES | RHONE-POULENC CHIMIE (FR) | 1990-03-21 | — | — | EP | disclosed |
| US-4745193-A | Process for the preparation of fluoromethylpyridines | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1988-05-17 | — | — | US | disclosed |
| US-4745193-A | Process for the preparation of fluoromethylpyridines | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1988-05-17 | — | — | US | disclosed |
| US-4745193-A | Process for the preparation of fluoromethylpyridines | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1988-05-17 | — | — | US | disclosed |
| US-4692184-A | HERBICIDES | MONSANTO COMPANY (US) | 1987-09-08 | — | — | US | disclosed |
| EP-0063872-B1 | PROCESS FOR THE PREPARATION OF FLUOROMETHYL PYRIDINES AND CERTAIN NOVEL PRODUCTS OBTAINED THEREFROM | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1985-07-17 | — | — | EP | disclosed |
| EP-0063872-A1 | Process for the preparation of fluoromethyl pyridines and certain novel products obtained therefrom | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1982-11-03 | — | — | EP | disclosed |
| EP-0063872-A1 | Process for the preparation of fluoromethyl pyridines and certain novel products obtained therefrom | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1982-11-03 | — | — | EP | disclosed |
| US-4249009-A | Processes for preparing 2-chloro-5-trifluoromethylpyridine | REILLY TAR & CHEMICAL CORP. (US) | 1981-02-03 | — | — | US | disclosed |
| US-4249009-A | Processes for preparing 2-chloro-5-trifluoromethylpyridine | REILLY TAR & CHEMICAL CORP. (US) | 1981-02-03 | — | — | US | disclosed |