Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 6/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | CASP3 | P42574 | 3/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.34 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | CCNC | P24863 | 1/20 | 0.33 |
| ▸ | CDK8 | P49336 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20450508 | 0.87 | LMNA (0.38) | LMNAMAPTHTTKMT2AMEN1 | |
| SCHEMBL14077456 | 0.82 | HTT (0.42) | LMNAMAPTHTTCASP3MAPK8 | |
| SCHEMBL27872993 | 0.81 | CYP1A2 (0.38) | LMNAHTTKMT2AMEN1CASP3 | |
| SCHEMBL1047655 | 0.80 | ALDH1A1 (0.36) | LMNAMAPTHTTKMT2AMEN1 | |
| SCHEMBL30620821 | 0.79 | HTT (0.36) | LMNAMAPTHTTCASP3MAPK8 | |
| SCHEMBL13106339 | 0.73 | CASP3 (0.48) | LMNAHTTKMT2AMEN1CASP3 | |
| SCHEMBL22164595 | 0.72 | HTT (0.41) | LMNAMAPTHTTKMT2AMEN1 | |
| SCHEMBL1048915 | 0.71 | CASP3 (0.40) | LMNAHTTKMT2AMEN1CASP3 | |
| SCHEMBL17459798 | 0.71 | HTT (0.42) | LMNAHTTCASP3MAPK8ALDH1A1 | |
| SCHEMBL13106483 | 0.71 | CASP3 (0.40) | LMNAHTTCASP3L3MBTL1MAPK8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3902803-A1 | AZA-HETEROBICYCLIC INHIBITORS OF MAT2A AND METHODS OF USE FOR TREATING CANCER | Les Laboratoires Servier SAS (FR) | 2021-11-03 | — | — | EP | disclosed |
| WO-2020139991-A1 | AZA-HETEROBICYCLIC INHIBITORS OF MAT2A AND METHODS OF USE FOR TREATING CANCER | AGIOS PHARMACEUTICALS, INC. (US) | 2020-07-02 | — | — | WO | disclosed |