Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AR | P10275 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | RORC | P51449 | 1/20 | 0.33 |
| ▸ | PDE2A | O00408 | 1/20 | 0.33 |
| ▸ | LATS1 | O95835 | 1/20 | 0.33 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.33 |
| ▸ | AAK1 | Q2M2I8 | 2/20 | 0.32 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 2/20 | 0.32 |
| ▸ | RAB9A | P51151 | 2/20 | 0.32 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24988968 | 0.87 | LIMK1 (0.35) | LIMK1ALDH1A1LATS1RPS6KA3AAK1 | |
| SCHEMBL19997547 | 0.86 | LIMK1 (0.36) | ARHTTTSHRLIMK1ALDH1A1 | |
| SCHEMBL18019706 | 0.82 | RPS6KA3 (0.34) | LIMK1ALDH1A1PDE2ALATS1RPS6KA3 | |
| SCHEMBL2737349 | 0.82 | RPS6KA3 (0.42) | LIMK1ALDH1A1LATS1RPS6KA3AAK1 | |
| SCHEMBL26272363 | 0.79 | RPS6KA3 (0.34) | LIMK1ALDH1A1LATS1RPS6KA3AAK1 | |
| SCHEMBL20940108 | 0.77 | RPS6KA3 (0.41) | HTTTSHRALDH1A1RORCLATS1 | |
| SCHEMBL10115538 | 0.77 | RPS6KA3 (0.41) | HTTTSHRALDH1A1RORCLATS1 | |
| SCHEMBL14612403 | 0.77 | RPS6KA3 (0.41) | HTTTSHRALDH1A1RORCLATS1 | |
| SCHEMBL25493980 | 0.75 | TSHR (0.41) | HTTTSHRALDH1A1RORCRPS6KA3 | |
| SCHEMBL28284268 | 0.75 | ALDH1A1 (0.35) | LIMK1ALDH1A1LATS1NPC1SLC22A12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10695337-B2 | Piperidin-4-yl azetidine derivatives as JAK1 inhibitors | INCYTE HOLDINGS CORPORATION (US) | 2020-06-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10695337-B2 | Piperidin-4-yl azetidine derivatives as JAK1 inhibitors | JAK1, JAK2, JAK3 | AR 2490/4885HTT 2771/4885TSHR 2546/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.