Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LIMK1 | P53667 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | HTR2A | P28223 | 1/20 | 0.33 |
| ▸ | HTR2C | P28335 | 1/20 | 0.33 |
| ▸ | HTR2B | P41595 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | ACHE | P22303 | 1/20 | 0.32 |
| ▸ | UBE2M | P61081 | 1/20 | 0.32 |
| ▸ | DCUN1D1 | Q96GG9 | 1/20 | 0.32 |
| ▸ | LATS1 | O95835 | 1/20 | 0.32 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.31 |
| ▸ | AAK1 | Q2M2I8 | 2/20 | 0.31 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.31 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23082973 | 0.87 | LIMK1 (0.38) | LIMK1LMNAMAPTMAPK1KDM4E | |
| SCHEMBL22166106 | 0.87 | AR (0.39) | LIMK1SMN1; SMN2ALDH1A1LATS1RPS6KA3 | |
| SCHEMBL18019706 | 0.80 | RPS6KA3 (0.34) | LIMK1ALDH1A1LATS1RPS6KA3AAK1 | |
| SCHEMBL2737349 | 0.79 | RPS6KA3 (0.42) | LIMK1HTR2CALDH1A1LATS1RPS6KA3 | |
| SCHEMBL21783997 | 0.78 | RPS6KA3 (0.40) | LMNAMAPTMAPK1HTR2AHTR2C | |
| SCHEMBL19406662 | 0.77 | TDP1 (0.34) | LIMK1LMNAKDM4ESMN1; SMN2ALDH1A1 | |
| SCHEMBL26272363 | 0.76 | RPS6KA3 (0.34) | LIMK1ALDH1A1LATS1RPS6KA3AAK1 | |
| SCHEMBL21311456 | 0.76 | P2RX7 (0.42) | MAPTMAPK1SMN1; SMN2ALDH1A1 | |
| SCHEMBL16442475 | 0.76 | P2RX7 (0.42) | MAPTMAPK1SMN1; SMN2ALDH1A1 | |
| SCHEMBL19406631 | 0.76 | KCNH2 (0.36) | LIMK1LMNAALDH1A1SLC22A12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230043959-A1 | PIPERIDIN-4-YL AZETIDINE DERIVATIVES AS JAK1 INHIBITORS | INCYTE CORPORATION | 2023-02-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230043959-A1 | PIPERIDIN-4-YL AZETIDINE DERIVATIVES AS JAK1 INHIBITORS | JAK1, JAK2, JAK3 | LIMK1 2526/4885LMNA 4686/4885MAPT 4384/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.