Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.52 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.52 |
| ▸ | CHRM4 | P08173 | 4/20 | 0.46 |
| ▸ | NAMPT | P43490 | 14/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | FNTA | P49354 | 1/20 | 0.41 |
| ▸ | FNTB | P49356 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25678889 | 0.87 | DPP8 (0.49) | DPP8DPP9CHRM4NAMPTCYP1A2 | |
| SCHEMBL21847864 | 0.83 | DPP8 (0.50) | DPP8DPP9NAMPT | |
| SCHEMBL25678375 | 0.82 | DPP8 (0.54) | DPP8DPP9CHRM4NAMPT | |
| SCHEMBL13018584 | 0.79 | DPP8 (0.60) | DPP8DPP9NAMPT | |
| SCHEMBL25678403 | 0.77 | DPP8 (0.46) | DPP8DPP9CHRM4NAMPTFNTA | |
| SCHEMBL25678398 | 0.77 | NAMPT (0.52) | DPP8DPP9NAMPT | |
| SCHEMBL13195462 | 0.76 | DPP8 (0.53) | DPP8DPP9NAMPT | |
| SCHEMBL15490032 | 0.76 | DPP8 (0.60) | DPP8DPP9NAMPT | |
| SCHEMBL25678333 | 0.75 | CHRM4 (0.36) | CHRM4CYP1A2FNTAFNTB | |
| SCHEMBL3438648 | 0.74 | NOTUM (0.61) | DPP8DPP9NAMPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230192690-A1 | 5,7-DIHYDRO-PYRROLO-PYRIDINE DERIVATIVES | PFIZER (US) | 2023-06-22 | — | — | US | disclosed |
| US-20230192690-A1 | 5,7-DIHYDRO-PYRROLO-PYRIDINE DERIVATIVES | PFIZER (US) | 2023-06-22 | — | — | US | disclosed |
| US-20200207762-A1 | 5,7-DIHYDRO-PYRROLO-PYRIDINE DERIVATIVES | PFIZER (US) | 2020-07-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200207762-A1 | 5,7-DIHYDRO-PYRROLO-PYRIDINE DERIVATIVES | CHRM1, CHRM5, CHRM2 | DPP8 3990/4885DPP9 4375/4885CHRM4 4/4885 |
| US-20230192690-A1 | 5,7-DIHYDRO-PYRROLO-PYRIDINE DERIVATIVES | CHRM1, CHRM5, CHRM2 | DPP8 3990/4885DPP9 4375/4885CHRM4 4/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.