Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IMPDH2 | P12268 | 17/20 | 0.60 |
| ▸ | IMPDH1 | P20839 | 7/20 | 0.60 |
| ▸ | AAK1 | Q2M2I8 | 2/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28710975 | 0.88 | IMPDH2 (0.47) | IMPDH2IMPDH1AAK1KDM4ENPC1 | |
| SCHEMBL5777067 | 0.84 | IMPDH2 (0.56) | IMPDH2IMPDH1AAK1KDM4ENPC1 | |
| SCHEMBL22188032 | 0.81 | IMPDH2 (0.60) | IMPDH2IMPDH1AAK1 | |
| SCHEMBL21757560 | 0.79 | IMPDH2 (0.74) | IMPDH2IMPDH1AAK1 | |
| SCHEMBL23493611 | 0.79 | LMNA (0.53) | IMPDH2IMPDH1AAK1 | |
| SCHEMBL29541692 | 0.78 | IMPDH2 (0.49) | IMPDH2IMPDH1AAK1KDM4ENPC1 | |
| SCHEMBL2898349 | 0.76 | GAA (0.53) | IMPDH2IMPDH1AAK1 | |
| SCHEMBL29454983 | 0.76 | IMPDH2 (0.60) | IMPDH2IMPDH1AAK1KDM4ENPC1 | |
| SCHEMBL30177609 | 0.76 | IMPDH2 (0.50) | IMPDH2IMPDH1AAK1KDM4ENPC1 | |
| SCHEMBL5780722 | 0.76 | IMPDH2 (0.60) | IMPDH2IMPDH1AAK1KDM4ENPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3902798-B1 | N-(4-(OXAZOL-5-YL)PHENYL)CHROMANE-3-CARBOXAMIDE DERIVATIVES AND RELATED COMPOUNDS AS STIMULATORS OF THE PRODUCTION OF RETINAL PRECURSOR CELLS FOR THE TREATMENT OF NEURORETINAL DISEASES | ENDOGENA THERAPEUTICS INC (US) | 2023-12-20 | — | — | EP | disclosed |
| WO-2020140043-A1 | COMPOUNDS FOR USE AS THERAPEUTICALLY ACTIVE SUBSTANCES IN THE TREATMENT AND/OR PREVENTION OF NEURORETINAL DISEASES | ENDOGENA THERAPEUTICS, INC. (US) | 2020-07-02 | — | — | WO | disclosed |
| WO-2020140050-A1 | N-(4-(OXAZOL-5-YL)PHENYL)CHROMANE-3-CARBOXAMIDE DERIVATIVES AND RELATED COMPOUNDS AS STIMULATORS OF THE PRODUCTION OF RETINAL PRECURSOR CELLS FOR THE TREATMENT OF NEURORETINAL DISEASES | ENDOGENA THERAPEUTICS, INC. (US) | 2020-07-02 | — | — | WO | disclosed |