Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2B | P29275 | 5/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 8/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 8/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.36 |
| ▸ | CASP1 | P29466 | 4/20 | 0.36 |
| ▸ | CASP7 | P55210 | 4/20 | 0.36 |
| ▸ | LMNA | P02545 | 3/20 | 0.36 |
| ▸ | USP2 | O75604 | 3/20 | 0.36 |
| ▸ | TSHR | P16473 | 3/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.35 |
| ▸ | WEE1 | P30291 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2216088 | 0.70 | NOX4 (0.65) | CYP3A4CYP2C19CYP2C9NOX4 | |
| SCHEMBL2217610 | 0.70 | NOX4 (0.48) | CYP3A4ALDH1A1CYP2C19CYP2C9NOX4 | |
| SCHEMBL14936168 | 0.58 | MPO (0.49) | CYP1A2ALDH1A1HSD17B10CASP1CASP7 | |
| SCHEMBL10900030 | 0.58 | KMT2A (0.41) | CYP1A2ALDH1A1HSD17B10MAPK1KMT2A | |
| SCHEMBL155729 | 0.56 | TSHR (0.61) | ALDH1A1TSHRTDP1SMN1; SMN2 | |
| Anthraquinone SCHEMBL8469578 | 0.56 | TSHR (0.68) | ALDH1A1LMNATSHRMAPK1KMT2A | |
| Methoxymethane SCHEMBL27428029 | 0.56 | TSHR (0.83) | ALDH1A1TSHRMAPK1KMT2ATDP1 | |
| SCHEMBL28301231 | 0.56 | TSHR (0.83) | ALDH1A1TSHRMAPK1KMT2ATDP1 | |
| SCHEMBL10709681 | 0.55 | TSHR (0.58) | ALDH1A1LMNATSHRTDP1SMN1; SMN2 | |
| SCHEMBL5350601 | 0.55 | TSHR (0.58) | ALDH1A1LMNATSHRTDP1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110178081-A1 | PYRAZOLO PYRIDINE DERIVATIVES AS NADPH OXIDASE INHIBITORS | GENKYOTEX SA (CH) | 2011-07-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110178081-A1 | PYRAZOLO PYRIDINE DERIVATIVES AS NADPH OXIDASE INHIBITORS | NOX1, NOX4, CYBB | ADORA2B 1443/4885CYP1A2 63/4885CYP3A4 157/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.