Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22175901 | 0.90 | MAPT (0.46) | ALDH1A1HSP90AA1MAPTCYP2C9CYP1A2 | |
| SCHEMBL22176051 | 0.88 | L3MBTL4 (0.48) | ALDH1A1HSP90AA1MAPTCYP2C9CYP1A2 | |
| Hydrochloric Acid SCHEMBL22164285 | 0.87 | L3MBTL4 (0.47) | ALDH1A1HSP90AA1MAPTCYP2C9CYP1A2 | |
| SCHEMBL19684886 | 0.86 | ALDH1A1 (0.50) | ALDH1A1HSP90AA1MAPTCYP2C9CYP1A2 | |
| SCHEMBL22176108 | 0.86 | KDM4E (0.48) | ALDH1A1HSP90AA1MAPTCYP2C9CYP1A2 | |
| SCHEMBL18914159 | 0.85 | MAPT (0.48) | ALDH1A1HSP90AA1MAPTCYP2C9CYP1A2 | |
| Hydrochloric Acid SCHEMBL22164308 | 0.85 | KDM4E (0.47) | ALDH1A1HSP90AA1MAPTCYP2C9CYP1A2 | |
| SCHEMBL22176383 | 0.84 | ALDH1A1 (0.50) | ALDH1A1HSP90AA1MAPTCYP2C9CYP1A2 | |
| Hydrochloric Acid SCHEMBL22164245 | 0.83 | MAPT (0.47) | ALDH1A1HSP90AA1MAPTCYP2C9CYP1A2 | |
| Hydrochloric Acid SCHEMBL22164206 | 0.83 | ALDH1A1 (0.49) | ALDH1A1HSP90AA1MAPTCYP2C9CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230069963-A1 | PYRAZOLO[1,5-A]PYRIMIDINE MACROCYCLIC COMPOUND | TAISHO PHARMACEUTICAL CO., LTD. (JP) | 2023-03-09 | — | — | US | disclosed |
| EP-3903788-A1 | PYRAZOLO[1,5-A]PYRIMIDINE MACROCYCLIC COMPOUND | Taisho Pharmaceutical Co., Ltd. (JP) | 2021-11-03 | — | — | EP | disclosed |
| WO-2020138015-A1 | PYRAZOLO[1,5-A]PYRIMIDINE MACROCYCLIC COMPOUND | 大正製薬株式会社 | 2020-07-02 | — | — | WO | disclosed |
| WO-2020138015-A1 | PYRAZOLO[1,5-A]PYRIMIDINE MACROCYCLIC COMPOUND | 大正製薬株式会社 | 2020-07-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230069963-A1 | PYRAZOLO[1,5-A]PYRIMIDINE MACROCYCLIC COMPOUND | ZC3HAV1, ZC3HAV1L, IL5 | ALDH1A1 2801/4885HSP90AA1 4065/4885MAPT 4295/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.