Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL221800 | 1.00 | MDM2 (1.00) | MDM2TP53 | |
| SCHEMBL29776615 | 1.00 | MDM2 (1.00) | MDM2TP53 | |
| SCHEMBL10299795 | 1.00 | MDM2 (1.00) | MDM2TP53 | |
| SCHEMBL222901 | 1.00 | MDM2 (1.00) | MDM2TP53 | |
| SCHEMBL222900 | 1.00 | MDM2 (1.00) | MDM2TP53 | |
| SCHEMBL29776561 | 0.95 | MDM2 (0.90) | MDM2TP53 | |
| SCHEMBL222465 | 0.95 | MDM2 (0.90) | MDM2TP53 | |
| SCHEMBL1956570 | 0.95 | MDM2 (0.90) | MDM2TP53 | |
| SCHEMBL222469 | 0.95 | MDM2 (0.90) | MDM2TP53 | |
| SCHEMBL10299791 | 0.95 | MDM2 (0.90) | MDM2TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3498712-B1 | SPIROCYCLIC INDOLONE POLYETHYLENE GLYCOL CARBONATE COMPOUND, COMPOSITION, PREPARATION METHOD AND USE THEREOF | JIANGSU YAYO BIOTECHNOLOGY CO LTD (CN) | 2024-01-03 | — | — | EP | claimed |
| US-8088815-B2 | Spiroindolinone pyrrolidines | HOFFMAN-LA ROCHE INC. (US) | 2012-01-03 | — | — | US | claimed |
| EP-3498712-B1 | SPIROCYCLIC INDOLONE POLYETHYLENE GLYCOL CARBONATE COMPOUND, COMPOSITION, PREPARATION METHOD AND USE THEREOF | JIANGSU YAYO BIOTECHNOLOGY CO LTD (CN) | 2024-01-03 | — | — | EP | disclosed |
| US-10471154-B2 | Spirocyclic indolone polyethylene glycol carbonate compound, composition, preparation method and use thereof | Xiao, Fei (CN) | 2019-11-12 | — | — | US | disclosed |
| US-10471154-B2 | Spirocyclic indolone polyethylene glycol carbonate compound, composition, preparation method and use thereof | Xiao, Fei (CN) | 2019-11-12 | — | — | US | disclosed |
| US-20190209700-A1 | SPIROCYCLIC INDOLONE POLYETHYLENE GLYCOL CARBONATE COMPOUND, COMPOSITION, PREPARATION METHOD AND USE THEREOF | JIANGSU YAYO BIOTECHNOLOGY CO. LTD. (CN) | 2019-07-11 | — | — | US | disclosed |
| US-20190209700-A1 | SPIROCYCLIC INDOLONE POLYETHYLENE GLYCOL CARBONATE COMPOUND, COMPOSITION, PREPARATION METHOD AND USE THEREOF | JIANGSU YAYO BIOTECHNOLOGY CO. LTD. (CN) | 2019-07-11 | — | — | US | disclosed |
| EP-3498712-A1 | SPIROCYCLIC INDOLONE POLYETHYLENE GLYCOL CARBONATE COMPOUND, COMPOSITION, PREPARATION METHOD AND USE THEREOF | Xiao, Fei (CN) | 2019-06-19 | — | — | EP | disclosed |
| EP-3498712-A1 | SPIROCYCLIC INDOLONE POLYETHYLENE GLYCOL CARBONATE COMPOUND, COMPOSITION, PREPARATION METHOD AND USE THEREOF | Xiao, Fei (CN) | 2019-06-19 | — | — | EP | disclosed |
| WO-2018027477-A1 | SPIROCYCLIC INDOLONE POLYETHYLENE GLYCOL CARBONATE COMPOUND, COMPOSITION, PREPARATION METHOD AND USE THEREOF | 肖飞 | 2018-02-15 | — | — | WO | disclosed |
| US-8088815-B2 | Spiroindolinone pyrrolidines | HOFFMAN-LA ROCHE INC. (US) | 2012-01-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10471154-B2 | Spirocyclic indolone polyethylene glycol carbonate compound, composition, preparation method and use thereof | SI, MKI67, HSD17B7 | MDM2 633/4885TP53 43/4885 |
| US-20190209700-A1 | SPIROCYCLIC INDOLONE POLYETHYLENE GLYCOL CARBONATE COMPOUND, COMPOSITION, PREPARATION METHOD AND USE THEREOF | SI, HSD17B7, MKI67 | MDM2 621/4885TP53 43/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.