Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | LPAR2 | Q9HBW0 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 2/20 | 0.41 |
| ▸ | IKBKB | O14920 | 1/20 | 0.40 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.40 |
| ▸ | UBE2N | P61088 | 1/20 | 0.40 |
| ▸ | CASP1 | P29466 | 1/20 | 0.40 |
| ▸ | CASP7 | P55210 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22181986 | 0.93 | SIRT1 (0.47) | POLBMAPTKDM4EALDH1A1HPGD | |
| SCHEMBL22181889 | 0.86 | LPAR2 (0.52) | MAPTKDM4EALDH1A1HPGDLPAR2 | |
| SCHEMBL22181891 | 0.83 | CYP1A2 (0.46) | POLBMAPTKDM4EALDH1A1HPGD | |
| SCHEMBL22181861 | 0.81 | SIRT1 (0.53) | POLBMAPTKDM4EALDH1A1HPGD | |
| SCHEMBL22182117 | 0.79 | SIRT1 (0.50) | POLBMAPTKDM4EALDH1A1HPGD | |
| SCHEMBL22181935 | 0.77 | SIRT1 (0.46) | MAPTKDM4EALDH1A1HPGDSIRT1 | |
| SCHEMBL22181871 | 0.77 | ALDH1A1 (0.55) | POLBMAPTKDM4EALDH1A1HPGD | |
| SCHEMBL22181894 | 0.77 | SIRT1 (0.53) | POLBMAPTKDM4EALDH1A1HPGD | |
| SCHEMBL22181892 | 0.77 | SIRT1 (0.51) | POLBMAPTALDH1A1HPGDSIRT1 | |
| SCHEMBL22181854 | 0.77 | SIRT1 (0.57) | POLBMAPTKDM4EALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020139291-A1 | NAPHTHALIMIDE DERIVATIVES AS ANTI-PARASITIC AGENTS FOR THE TREATMENT OF LEISHMANIASIS AS WELL AS VIRAL, BACTERIAL AND NEOPLASTIC DISEASES | ISTANBUL MEDIPOL UNIVERSITESI (TR) | 2020-07-02 | — | — | WO | disclosed |