Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.47 |
| ▸ | AHR | P35869 | 1/20 | 0.47 |
| ▸ | RAD52 | P43351 | 1/20 | 0.47 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.47 |
| ▸ | SIRT1 | Q96EB6 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 4/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.45 |
| ▸ | HPGD | P15428 | 3/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | THRB | P10828 | 1/20 | 0.45 |
| ▸ | HEXA | P06865 | 2/20 | 0.44 |
| ▸ | HEXB | P07686 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22182008 | 0.83 | ALDH1A1 (0.46) | ALDH1A1KDM4EPOLBLMNANR1I2 | |
| SCHEMBL22181899 | 0.82 | MEN1 (0.56) | ALDH1A1KDM4EPOLBLMNASIRT1 | |
| SCHEMBL22182064 | 0.81 | ALDH1A1 (0.52) | ALDH1A1KDM4ECYP1A2CYP3A4CYP2D6 | |
| SCHEMBL22182021 | 0.80 | HDAC3 (0.50) | ALDH1A1KDM4ECYP1A2CYP3A4CYP2D6 | |
| SCHEMBL22181998 | 0.79 | SIRT1 (0.53) | ALDH1A1KDM4ECYP1A2CYP3A4CYP2D6 | |
| SCHEMBL22181915 | 0.79 | ALDH1A1 (0.57) | ALDH1A1KDM4EPOLBLMNASIRT1 | |
| SCHEMBL22181855 | 0.78 | TP53 (0.53) | ALDH1A1KDM4ECYP1A2CYP3A4CYP2D6 | |
| SCHEMBL22181997 | 0.75 | ALDH1A1 (0.52) | ALDH1A1KDM4ECYP1A2CYP3A4CYP2D6 | |
| SCHEMBL22182092 | 0.73 | HDAC3 (0.52) | ALDH1A1KDM4ECYP1A2CYP3A4CYP2D6 | |
| SCHEMBL22181908 | 0.73 | MEN1 (0.55) | ALDH1A1KDM4EPOLBSIRT1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220143005-A1 | NAPHTHALIMIDE DERIVATIVES AS ANTI-PARASITIC AGENTS FOR THE TREATMENT OF LEISHMANIASIS AS WELL AS VIRAL, BACTERIAL AND NEOPLASTIC DISEASES | ISTANBUL MEDIPOL UNIVERSITESI (TR) | 2022-05-12 | — | — | US | disclosed |
| WO-2020139291-A1 | NAPHTHALIMIDE DERIVATIVES AS ANTI-PARASITIC AGENTS FOR THE TREATMENT OF LEISHMANIASIS AS WELL AS VIRAL, BACTERIAL AND NEOPLASTIC DISEASES | ISTANBUL MEDIPOL UNIVERSITESI (TR) | 2020-07-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220143005-A1 | NAPHTHALIMIDE DERIVATIVES AS ANTI-PARASITIC AGENTS FOR THE TREATMENT OF LEISHMANIASIS AS WELL AS VIRAL, BACTERIAL AND NEOPLASTIC DISEASES | NPM1, ECI1, IPO5 | ALDH1A1 785/4885KDM4E 1050/4885CYP1A2 2231/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.