SCHEMBL2218286

SCHEMBL2218286

CN(C)C(=O)C=Cc1ccc(N)cc1

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 3/20 0.49
MAPT P10636 3/20 0.49
RAB9A P51151 3/20 0.49
KMT2A Q03164 3/20 0.49
NPC1 O15118 3/20 0.49
NFKB1 P19838 2/20 0.49
NFKB2 Q00653 2/20 0.49
RELA Q04206 2/20 0.49
ALDH1A1 P00352 1/20 0.49
LMNA P02545 1/20 0.49
HTT P42858 1/20 0.49
SMN1; SMN2 Q16637 1/20 0.49
CYP1B1 Q16678 1/20 0.47
HSD17B3 P37058 1/20 0.47
L3MBTL1 Q9Y468 2/20 0.46
PSMD14 O00487 1/20 0.46
CRHBP P24387 1/20 0.46
CRHR2 Q13324 1/20 0.46
APP P05067 2/20 0.45
CYP19A1 P11511 2/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9720425 1.00 MEN1 (0.49) MEN1MAPTRAB9AKMT2ANPC1
SCHEMBL11217696 0.90 HSD17B3 (0.55) MAPTRAB9ANPC1ALDH1A1LMNA
SCHEMBL10716746 0.82 TYR (0.61) MAPTRAB9AKMT2ANFKB1NFKB2
SCHEMBL28375640 0.82 TRPM8 (0.49) MAPTRAB9AKMT2ANPC1ALDH1A1
SCHEMBL10716741 0.82 TYR (0.61) MAPTRAB9AKMT2ANFKB1NFKB2
SCHEMBL9743178 0.81 CYP19A1 (0.49) MEN1MAPTRAB9AKMT2ANPC1
SCHEMBL9743187 0.81 CYP19A1 (0.49) MEN1MAPTRAB9AKMT2ANPC1
SCHEMBL16431497 0.81 MAPT (0.57) MEN1MAPTKMT2AALDH1A1LMNA
SCHEMBL3413340 0.81 CYP1A2 (0.62) MEN1MAPTRAB9AKMT2ANPC1
SCHEMBL1016905 0.81 MAPT (0.57) MEN1MAPTKMT2AALDH1A1LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4647625-A Process for modifying conjugated diene polymers NIPPON ZEON CO., LTD. (JP) 1987-03-03 US claimed
EP-2666814-B1 ELECTRICALLY CONDUCTIVE RUBBER ELASTOMER, CHARGING MEMBER, AND ELECTROPHOTOGRAPHIC APPARATUS CANON KK (JP) 2018-03-14 EP disclosed
CN-103328561-B Electrically conductive rubber elastomer, charging member, and electrophotographic apparatus CANON KK 2014-12-10 CN disclosed
EP-2490077-B1 ELECTRIFICATING MEMBER AND ELECTROPHOTOGRAPHIC DEVICE CANON KK (JP) 2014-10-01 EP disclosed
US-8750762-B2 Charging member with vulcanized rubber, and electrophotographic apparatus including the charging member CANON KABUSHIKI KAISHA (JP) 2014-06-10 US disclosed
EP-2666814-A1 ELECTRICALLY CONDUCTIVE RUBBER ELASTOMER, CHARGING MEMBER, AND ELECTROPHOTOGRAPHIC APPARATUS Canon Kabushiki Kaisha (JP) 2013-11-27 EP disclosed
CN-103328561-A Electrically conductive rubber elastomer, charging member, and electrophotographic apparatus CANON KK 2013-09-25 CN disclosed
US-8491994-B2 Conductive rubber elastic material, charging member and electrophotographic apparatus CANON KABUSHIKI KAISHA (JP) 2013-07-23 US disclosed
US-8367775-B2 Modified conjugated diene-vinyl aromatic copolymer and method for manufacturing the same CHI MEI CORPORATION (TW) 2013-02-05 US disclosed
US-20120224887-A1 CONDUCTIVE RUBBER ELASTIC MATERIAL, CHARGING MEMBER AND ELECTROPHOTOGRAPHIC APPARATUS CANON KABUSHIKI KAISHA (JP) 2012-09-06 US disclosed
EP-2490077-A1 ELECTRIFICATING MEMBER AND ELECTROPHOTOGRAPHIC DEVICE Canon Kabushiki Kaisha (JP) 2012-08-22 EP disclosed
US-20120172526-A1 MODIFIED CONJUGATED DIENE-VINYL AROMATIC COPOLYMER AND METHOD FOR MANUFACTURING THE SAME CHI MEI CORPORATION (TW) 2012-07-05 US disclosed
US-20110176833-A1 CHARGING MEMBER AND ELECTROPHOTOGRAPHIC APPARATUS CANON KABUSHIKI KAISHA (JP) 2011-07-21 US disclosed
US-5115006-A Modified conjugated diene rubber with alkali or alkaline earth metals, and amine NIPPON ZEON CO., LTD. (JP) 1992-05-19 US disclosed
US-4950719-A LOW TEMPERATURE VIBRATION INSULATOR NIPPON ZEON CO., LTD. (JP) 1990-08-21 US disclosed
EP-0150479-B1 PROCESS FOR MODIFYING CONJUGATED DIENE POLYMERS NIPPON ZEON CO., LTD. (JP) 1990-06-13 EP disclosed
US-4929679-A BUTADIENE-STYRENE COPOLYMERS BLENDS WITH NATURAL RUBBERS OR POLYISOPRENE, WEAR RESISTANCE NIPPON ZEON CO., LTD. (JP) 1990-05-29 US disclosed
US-4786680-A NONSKIDDING, NATURAL RUBBER, POLYISOPRENE, SBR, HALOGENATED BUTYL RUBBER THE YOKOHAMA RUBBER CO., LTD. (JP) 1988-11-22 US disclosed
US-4647625-A Process for modifying conjugated diene polymers NIPPON ZEON CO., LTD. (JP) 1987-03-03 US disclosed
EP-0150479-A2 Process for modifying conjugated diene polymers NIPPON ZEON CO., LTD. (JP) 1985-08-07 EP disclosed