Known targets — ChEMBL curated mechanism
ADRB1CDK4CDK6CHRM2CHRM3DPP4DRD2DRD3DRD4EGFRHRH1HTR1BHTR1DHTR1FHTR2AHTR2CHTR4SLC6A2SLC6A4
The experimentally established mechanism targets of Succinic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CAMK2A | Q9UQM7 | 1/20 | 0.59 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.48 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.48 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 4/20 | 0.43 |
| ▸ | EGLN1 | Q9GZT9 | 2/20 | 0.43 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.43 |
| ▸ | SUCNR1 | Q9BXA5 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | SLC13A3 | Q8WWT9 | 1/20 | 0.40 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.40 |
| ▸ | TBXAS1 | P24557 | 2/20 | 0.40 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.38 |
| ▸ | FNTA | P49354 | 1/20 | 0.38 |
| ▸ | FNTB | P49356 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL523411 | 0.93 | CAMK2A (0.52) | CAMK2AGPR84FFAR1FFAR4LMNA | |
| SCHEMBL16091 | 0.93 | — | — | |
| SCHEMBL3458521 | 0.88 | CAMK2A (0.48) | CAMK2AGPR84FFAR1FFAR4TBXAS1 | |
| Acetone SCHEMBL8337322 | 0.86 | CAMK2A (0.46) | CAMK2AGPR84FFAR1FFAR4TBXAS1 | |
| SCHEMBL16665 | 0.85 | GPR84 (0.52) | CAMK2AGPR84FFAR1FFAR4LMNA | |
| Succinic Acid SCHEMBL2484910 | 0.85 | LMNA (0.47) | CAMK2AGPR84FFAR1FFAR4LMNA | |
| Sulfuric Acid SCHEMBL3414917 | 0.84 | CAMK2A (0.44) | CAMK2AGPR84FFAR1FFAR4TBXAS1 | |
| Phosphoric Acid SCHEMBL16371862 | 0.84 | CAMK2A (0.44) | CAMK2AGPR84FFAR1FFAR4TBXAS1 | |
| Phosphoric Acid SCHEMBL1133558 | 0.84 | CAMK2A (0.44) | CAMK2AGPR84FFAR1FFAR4TBXAS1 | |
| Methacrylic Acid SCHEMBL5870670 | 0.84 | CAMK2A (0.44) | CAMK2AGPR84FFAR1FFAR4TBXAS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10222721-B2 | Urethane foam and toner-conveying roller using the same | BRIDGESTONE CORPORATION (JP) | 2019-03-05 | — | — | US | disclosed |
| US-9563154-B2 | Toner transfer roller and image forming device using the same | BRIDGESTONE CORPORATION (JP) | 2017-02-07 | — | — | US | disclosed |
| US-9316958-B2 | Charge-controlled polyurethane foam and toner-conveying roller using the same | BRIDGESTONE CORPORATION (JP) | 2016-04-19 | — | — | US | disclosed |
| US-8927071-B2 | Pressure-sensitive adhesive composition, pressure-sensitive adhesive and optical film | NIPPON CARBIDE INDUSTRIES CO., INC. (JP) | 2015-01-06 | — | — | US | disclosed |
| EP-1496089-B1 | Antifouling coating | NIPPON PAINT CO LTD (JP) | 2011-11-02 | — | — | EP | disclosed |
| US-20110236605-A1 | PRESSURE-SENSITIVE ADHESIVE COMPOSITION, PRESSURE-SENSITIVE ADHESIVE AND OPTICAL FILM | NIPPON CARBIDE INDUSTRIES CO., INC. (JP) | 2011-09-29 | — | — | US | disclosed |
| US-20110188900-A1 | URETHANE FOAM AND TONER-CONVEYING ROLLER USING THE SAME | BRIDGESTONE CORPORATION (JP) | 2011-08-04 | — | — | US | disclosed |
| US-20110177926-A1 | CHARGE-CONTROLLED POLYURETHANE FOAM AND TONER-CONVEYING ROLLER USING THE SAME | BRIDGESTONE CORPORATION (JP) | 2011-07-21 | — | — | US | disclosed |
| US-20100158579-A1 | TONER TRANSFER ROLLER AND IMAGE FORMING DEVICE USING THE SAME | BRIDGESTONE CORPORATION (JP) | 2010-06-24 | — | — | US | disclosed |