Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.56 |
| ▸ | MAPT | P10636 | 3/20 | 0.56 |
| ▸ | GRIN2D | O15399 | 2/20 | 0.56 |
| ▸ | GRIN3B | O60391 | 2/20 | 0.56 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.56 |
| ▸ | GRIN2A | Q12879 | 2/20 | 0.56 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.56 |
| ▸ | GRIN2C | Q14957 | 2/20 | 0.56 |
| ▸ | GRIN3A | Q8TCU5 | 2/20 | 0.56 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.47 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.41 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14531196 | 1.00 | SIGMAR1 (0.56) | SIGMAR1MAPTGRIN2DGRIN3BGRIN1 | |
| SCHEMBL1604532 | 1.00 | SIGMAR1 (0.56) | SIGMAR1MAPTGRIN2DGRIN3BGRIN1 | |
| SCHEMBL1606356 | 1.00 | SIGMAR1 (0.56) | SIGMAR1MAPTGRIN2DGRIN3BGRIN1 | |
| SCHEMBL1606353 | 1.00 | SIGMAR1 (0.56) | SIGMAR1MAPTGRIN2DGRIN3BGRIN1 | |
| SCHEMBL3067249 | 0.86 | MAPT (0.60) | SIGMAR1MAPTGRIN2DGRIN3BGRIN1 | |
| SCHEMBL3064313 | 0.86 | SIGMAR1 (0.54) | SIGMAR1MAPTGRIN2DGRIN3BGRIN1 | |
| SCHEMBL3082238 | 0.83 | MAPT (0.70) | SIGMAR1MAPTGRIN2DGRIN3BGRIN1 | |
| SCHEMBL3071087 | 0.83 | MAPT (0.59) | SIGMAR1MAPTGRIN2DGRIN3BGRIN1 | |
| SCHEMBL3058571 | 0.82 | MAPT (0.51) | SIGMAR1MAPTGRIN2DGRIN3BGRIN1 | |
| SCHEMBL3065619 | 0.81 | SIGMAR1 (0.50) | SIGMAR1MAPTGRIN2DGRIN3BGRIN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8501954-B2 | Asymmetric process for making substituted 2-amino-thiazolones | AMGEN INC. (US) | 2013-08-06 | — | — | US | claimed |
| EP-2321290-B1 | ASYMMETRIC PROCESS FOR MAKING SUBSTITUTED 2-AMINO-THIAZOLONES | AMGEN INC (US) | 2012-06-20 | — | — | EP | claimed |
| US-20110178307-A1 | ASYMMETRIC PROCESS FOR MAKING SUBSTITUTED 2-AMINO-THIAZOLONES | AMGEN INC. (US) | 2011-07-21 | — | — | US | claimed |
| US-20130345432-A1 | ASYMMETRIC PROCESS FOR MAKING SUBSTITUTED 2-AMINO-THIAZOLONES | AMGEN INC. (US) | 2013-12-26 | — | — | US | disclosed |
| US-8501954-B2 | Asymmetric process for making substituted 2-amino-thiazolones | AMGEN INC. (US) | 2013-08-06 | — | — | US | disclosed |
| EP-2321290-B1 | ASYMMETRIC PROCESS FOR MAKING SUBSTITUTED 2-AMINO-THIAZOLONES | AMGEN INC (US) | 2012-06-20 | — | — | EP | disclosed |
| US-20110178307-A1 | ASYMMETRIC PROCESS FOR MAKING SUBSTITUTED 2-AMINO-THIAZOLONES | AMGEN INC. (US) | 2011-07-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110178307-A1 | ASYMMETRIC PROCESS FOR MAKING SUBSTITUTED 2-AMINO-THIAZOLONES | HSD11B1, HSD17B1, HSD17B2 | SIGMAR1 1280/4885MAPT 3189/4885GRIN2D 1075/4885 |
| US-20130345432-A1 | ASYMMETRIC PROCESS FOR MAKING SUBSTITUTED 2-AMINO-THIAZOLONES | HSD11B1, HSD17B1, HSD17B2 | SIGMAR1 1280/4885MAPT 3189/4885GRIN2D 1075/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.