Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM8 | Q7Z2W7 | 10/20 | 0.78 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.67 |
| ▸ | GABRA1 | P14867 | 3/20 | 0.60 |
| ▸ | GABRB2 | P47870 | 3/20 | 0.60 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.60 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.60 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.60 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.60 |
| ▸ | HPGD | P15428 | 2/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.54 |
| ▸ | NPC1 | O15118 | 1/20 | 0.54 |
| ▸ | RAB9A | P51151 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31490310 | 0.92 | TRPM8 (0.76) | TRPM8CYP3A4GABRA1GABRB2GABRG2 | |
| SCHEMBL28408661 | 0.88 | TRPM8 (1.00) | TRPM8CYP3A4GABRA1GABRB2GABRG2 | |
| SCHEMBL10270783 | 0.88 | TRPM8 (1.00) | TRPM8CYP3A4GABRA1GABRB2GABRG2 | |
| SCHEMBL29907816 | 0.84 | TRPM8 (0.78) | TRPM8CYP3A4GABRA1GABRB2GABRG2 | |
| SCHEMBL20777301 | 0.84 | TRPM8 (0.78) | TRPM8CYP3A4GABRA1GABRB2GABRG2 | |
| SCHEMBL29779969 | 0.84 | TRPM8 (0.78) | TRPM8CYP3A4GABRA1GABRB2GABRG2 | |
| SCHEMBL22074392 | 0.82 | TRPM8 (0.74) | TRPM8CYP3A4GABRA1GABRB2GABRG2 | |
| SCHEMBL20773111 | 0.82 | TRPM8 (0.74) | TRPM8CYP3A4GABRA1GABRB2GABRG2 | |
| SCHEMBL29779972 | 0.82 | TRPM8 (0.74) | TRPM8CYP3A4GABRA1GABRB2GABRG2 | |
| SCHEMBL19721140 | 0.81 | GABRA1 (0.84) | TRPM8CYP3A4GABRA1GABRB2GABRG2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3675809-A1 | USE OF PHYSIOLOGICAL COOLING ACTIVE INGREDIENTS, AND COMPOSITIONS COMPRISING SUCH ACTIVE INGREDIENTS | BASF SE (DE) | 2020-07-08 | — | — | EP | claimed |