Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Minoxidil. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | CRHBP | P24387 | 1/20 | 0.42 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.40 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.40 |
| ▸ | NUDT1 | P36639 | 3/20 | 0.39 |
| ▸ | IKBKB | O14920 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.37 |
| ▸ | HTR6 | P50406 | 1/20 | 0.37 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Minoxidil SCHEMBL7738837 | 0.96 | TSHR (0.41) | SMN1; SMN2LMNATSHRCYP1A2KMT2A | |
| Minoxidil SCHEMBL5694922 | 0.94 | SMN1; SMN2 (0.43) | SMN1; SMN2LMNATSHRCYP1A2KMT2A | |
| Minoxidil SCHEMBL638820 | 0.92 | SMN1; SMN2 (0.47) | SMN1; SMN2LMNATSHRCYP1A2KMT2A | |
| Minoxidil SCHEMBL29365549 | 0.92 | SMN1; SMN2 (0.47) | SMN1; SMN2LMNATSHRCYP1A2KMT2A | |
| Minoxidil SCHEMBL8860979 | 0.92 | SMN1; SMN2 (0.47) | SMN1; SMN2LMNATSHRCYP1A2KMT2A | |
| Minoxidil SCHEMBL29698 | 0.92 | SMN1; SMN2 (0.47) | SMN1; SMN2LMNATSHRCYP1A2KMT2A | |
| Minoxidil SCHEMBL3137104 | 0.91 | SMN1; SMN2 (0.46) | SMN1; SMN2LMNATSHRCYP1A2KMT2A | |
| Minoxidil SCHEMBL6242048 | 0.91 | SMN1; SMN2 (0.46) | SMN1; SMN2LMNATSHRCYP1A2KMT2A | |
| Minoxidil SCHEMBL7634414 | 0.91 | SMN1; SMN2 (0.46) | SMN1; SMN2LMNATSHRCYP1A2KMT2A | |
| Minoxidil SCHEMBL8080441 | 0.91 | SMN1; SMN2 (0.46) | SMN1; SMN2LMNATSHRCYP1A2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11628132-B2 | Minoxidil adjuvant therapies | Jupiter Wellness, Inc. (US) | 2023-04-18 | — | — | US | claimed |
| US-20200214958-A1 | Minoxidil Adjuvant Therapies | JUPITER WELLNESS INC. | 2020-07-09 | — | — | US | claimed |
| US-20230404886-A1 | MINOXIDIL ADJUVANT THERAPIES | Jupiter Wellness, Inc. (US) | 2023-12-21 | — | — | US | disclosed |
| CN-117243839-A | Minoxidil adjuvant therapy | 应用生物学股份有限公司 | 2023-12-19 | — | — | CN | disclosed |
| WO-2023239972-A1 | MINOXIDIL ADJUVANT THERAPIES | Jupiter Wellness, Inc. (US) | 2023-12-14 | — | — | WO | disclosed |
| US-11628132-B2 | Minoxidil adjuvant therapies | Jupiter Wellness, Inc. (US) | 2023-04-18 | — | — | US | disclosed |
| US-20200214958-A1 | Minoxidil Adjuvant Therapies | JUPITER WELLNESS INC. | 2020-07-09 | — | — | US | disclosed |