Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Minoxidil. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | CRHBP | P24387 | 1/20 | 0.41 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.41 |
| ▸ | IKBKB | O14920 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.39 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.39 |
| ▸ | NUDT1 | P36639 | 3/20 | 0.38 |
| ▸ | PARP1 | P09874 | 2/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | HTR6 | P50406 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Minoxidil SCHEMBL22189162 | 0.96 | SMN1; SMN2 (0.42) | TSHRSMN1; SMN2LMNACYP1A2KMT2A | |
| Minoxidil SCHEMBL5694922 | 0.93 | SMN1; SMN2 (0.43) | TSHRSMN1; SMN2LMNACYP1A2KMT2A | |
| Minoxidil SCHEMBL29365549 | 0.91 | SMN1; SMN2 (0.47) | TSHRSMN1; SMN2LMNACYP1A2KMT2A | |
| Minoxidil SCHEMBL638820 | 0.91 | SMN1; SMN2 (0.47) | TSHRSMN1; SMN2LMNACYP1A2KMT2A | |
| Minoxidil SCHEMBL8860979 | 0.91 | SMN1; SMN2 (0.47) | TSHRSMN1; SMN2LMNACYP1A2KMT2A | |
| Minoxidil SCHEMBL29698 | 0.91 | SMN1; SMN2 (0.47) | TSHRSMN1; SMN2LMNACYP1A2KMT2A | |
| Minoxidil SCHEMBL5080820 | 0.90 | SMN1; SMN2 (0.46) | TSHRSMN1; SMN2LMNACYP1A2KMT2A | |
| Minoxidil SCHEMBL6242048 | 0.90 | SMN1; SMN2 (0.46) | TSHRSMN1; SMN2LMNACYP1A2KMT2A | |
| Minoxidil SCHEMBL3137104 | 0.90 | SMN1; SMN2 (0.46) | TSHRSMN1; SMN2LMNACYP1A2KMT2A | |
| Minoxidil SCHEMBL8080441 | 0.90 | SMN1; SMN2 (0.46) | TSHRSMN1; SMN2LMNACYP1A2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20020182238-A1 | Fibers as anti-irritant agents | L'OREAL (FR) | 2002-12-05 | — | — | US | disclosed |