Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Minoxidil. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | CRHBP | P24387 | 1/20 | 0.46 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.46 |
| ▸ | HRH4 | Q9H3N8 | 6/20 | 0.44 |
| ▸ | NUDT1 | P36639 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.40 |
| ▸ | PDE4A | P27815 | 1/20 | 0.40 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.40 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.40 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.40 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | HTR6 | P50406 | 1/20 | 0.38 |
| ▸ | CASP1 | P29466 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Minoxidil SCHEMBL5080820 | 1.00 | SMN1; SMN2 (0.46) | SMN1; SMN2CRHBPCRHR2HRH4NUDT1 | |
| Minoxidil SCHEMBL6242048 | 1.00 | SMN1; SMN2 (0.46) | SMN1; SMN2CRHBPCRHR2HRH4NUDT1 | |
| Minoxidil SCHEMBL638820 | 0.98 | SMN1; SMN2 (0.47) | SMN1; SMN2CRHBPCRHR2HRH4NUDT1 | |
| Minoxidil SCHEMBL8860979 | 0.98 | SMN1; SMN2 (0.47) | SMN1; SMN2CRHBPCRHR2HRH4NUDT1 | |
| Minoxidil SCHEMBL29365549 | 0.98 | SMN1; SMN2 (0.47) | SMN1; SMN2CRHBPCRHR2HRH4NUDT1 | |
| Minoxidil SCHEMBL29698 | 0.98 | SMN1; SMN2 (0.47) | SMN1; SMN2CRHBPCRHR2HRH4NUDT1 | |
| Minoxidil SCHEMBL7634414 | 0.97 | SMN1; SMN2 (0.46) | SMN1; SMN2CRHBPCRHR2HRH4NUDT1 | |
| Minoxidil SCHEMBL3137104 | 0.97 | SMN1; SMN2 (0.46) | SMN1; SMN2CRHBPCRHR2HRH4NUDT1 | |
| SCHEMBL5309809 | 0.97 | HRH4 (0.46) | SMN1; SMN2CRHBPCRHR2HRH4NUDT1 | |
| Minoxidil SCHEMBL22189162 | 0.91 | SMN1; SMN2 (0.42) | SMN1; SMN2CRHBPCRHR2HRH4NUDT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1049473-A1 | PYRIMIDIN 3-OXIDE COMPOUNDS SUITABLE FOR THE TREATMENT OF PATHOLOGIES OF THE SKELETAL MUSCLE, IN PARTICULAR FOR THE TREATMENT OF THE HYPOKALEMIC PARALYSIS | Paolini, Moreno (IT) | 2000-11-08 | — | — | EP | disclosed |
| WO-1999036072-A1 | PYRIMIDIN 3-OXIDE COMPOUNDS SUITABLE FOR THE TREATMENT OF PATHOLOGIES OF THE SKELETAL MUSCLE, IN PARTICULAR FOR THE TREATMENT OF THE HYPOKALEMIC PARALYSIS | PAOLINI MORENO (IT) | 1999-07-22 | — | — | WO | disclosed |
| EP-0211268-B1 | SLOW-RELEASE TOPICAL FORMULATIONS | Zappia, Vincenzo (IT) | 1991-09-18 | — | — | EP | disclosed |
| EP-0211268-A2 | Slow-release topical formulations | Zappia, Vincenzo (IT) | 1987-02-25 | — | — | EP | disclosed |