Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 16/20 | 0.59 |
| ▸ | HSD17B10 | Q99714 | 13/20 | 0.59 |
| ▸ | CLK4 | Q9HAZ1 | 12/20 | 0.59 |
| ▸ | CYP2D6 | P10635 | 12/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 12/20 | 0.59 |
| ▸ | CYP3A4 | P08684 | 11/20 | 0.59 |
| ▸ | MAPK1 | P28482 | 7/20 | 0.58 |
| ▸ | TP53 | P04637 | 6/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.58 |
| ▸ | HPGD | P15428 | 5/20 | 0.58 |
| ▸ | MEN1 | O00255 | 3/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.58 |
| ▸ | MAPT | P10636 | 3/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.58 |
| ▸ | USP2 | O75604 | 2/20 | 0.56 |
| ▸ | CYP2C19 | P33261 | 11/20 | 0.56 |
| ▸ | TSHR | P16473 | 8/20 | 0.56 |
| ▸ | HIF1A | Q16665 | 5/20 | 0.56 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.52 |
| ▸ | CDC7 | O00311 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22191291 | 0.88 | CLK4 (0.46) | CYP1A2HSD17B10CLK4CYP2D6ALDH1A1 | |
| SCHEMBL16664936 | 0.84 | CDC25A (0.45) | CYP1A2HSD17B10CLK4CYP2D6ALDH1A1 | |
| SCHEMBL22191266 | 0.83 | TPH1 (0.49) | CYP1A2HSD17B10CLK4CYP2D6ALDH1A1 | |
| SCHEMBL22191334 | 0.80 | PLK4 (0.48) | CLK4ALDH1A1TP53KDM4EHPGD | |
| SCHEMBL22191355 | 0.80 | FYN (0.60) | CLK4MAPK1ROCK2PIM1PRKACA | |
| SCHEMBL22191614 | 0.78 | DYRK1A (0.54) | CLK4CDC7CDK2DYRK1ACLK1 | |
| SCHEMBL22191095 | 0.77 | PLK4 (0.50) | CLK4KMT2AMAPTPLK4CHEK1 | |
| SCHEMBL28644765 | 0.72 | PLK4 (0.55) | CLK4KDM4EMEN1KMT2AMAPT | |
| SCHEMBL22191227 | 0.72 | PDE3B (0.47) | CLK4KDM4EKMT2AMAPTPLK4 | |
| SCHEMBL22191476 | 0.71 | GAA (0.44) | CYP1A2CYP2D6ALDH1A1TP53KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220064146-A1 | KINASE INHIBITOR COMPOUNDS AND COMPOSITIONS AND METHODS OF USE | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2022-03-03 | — | — | US | disclosed |
| EP-3906028-A1 | KINASE INHIBITOR COMPOUNDS AND COMPOSITIONS AND METHODS OF USE | Icahn School of Medicine at Mount Sinai (US) | 2021-11-10 | — | — | EP | disclosed |
| CN-113543783-A | Kinase inhibitor compounds and compositions and methods of use | 西奈山伊坎医学院 | 2021-10-22 | — | — | CN | disclosed |
| WO-2020142486-A1 | KINASE INHIBITOR COMPOUNDS AND COMPOSITIONS AND METHODS OF USE | ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI (US) | 2020-07-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220064146-A1 | KINASE INHIBITOR COMPOUNDS AND COMPOSITIONS AND METHODS OF USE | CSNK1A1, MAP3K20, CSNK1G3 | CYP1A2 4688/4885HSD17B10 3368/4885CLK4 327/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.