Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GBA1 | P04062 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | MMP1 | P03956 | 2/20 | 0.39 |
| ▸ | MMP3 | P08254 | 2/20 | 0.39 |
| ▸ | MMP9 | P14780 | 2/20 | 0.39 |
| ▸ | PRKCD | Q05655 | 4/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | ABL1 | P00519 | 2/20 | 0.37 |
| ▸ | RIN1 | Q13671 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11396127 | 0.87 | TSHR (0.58) | TSHRHIF1AHSD17B10LMNAMEN1 | |
| SCHEMBL10714123 | 0.81 | PRKCD (0.42) | GBA1LMNAGAATP53PRKCD | |
| SCHEMBL27082407 | 0.81 | GAA (0.46) | GBA1TSHRHIF1AHSD17B10LMNA | |
| SCHEMBL1363122 | 0.79 | MMP1 (0.45) | GBA1TSHRHIF1AHSD17B10LMNA | |
| SCHEMBL11093126 | 0.78 | TSHR (0.55) | TSHRHIF1AHSD17B10LMNAMEN1 | |
| SCHEMBL11093813 | 0.78 | KMT2A (0.50) | TSHRHIF1AHSD17B10LMNAMEN1 | |
| SCHEMBL10633237 | 0.76 | GBA1 (0.46) | GBA1TSHRGAATP53PRKCD | |
| SCHEMBL11864710 | 0.75 | ALDH1A1 (0.37) | PRKCDKDM4EMEN1ALDH1A1MAPT | |
| SCHEMBL6235119 | 0.75 | GBA1 (0.53) | GBA1GAATP53PRKCDKDM4E | |
| SCHEMBL6231243 | 0.75 | GBA1 (0.53) | GBA1GAATP53PRKCDKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 333 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240197701-A1 | ANDROGEN RECEPTOR INHIBITION TO TREAT SEPSIS AND SHOCK | APPLIED BIOLOGY, INC. | 2024-06-20 | — | — | US | claimed |
| US-20220186227-A1 | Therapeutic Targets for Oncogenic KRAS-Dependent Cancers | UNIVERSITY OF MASSACHUSETTS | 2022-06-16 | — | — | US | claimed |
| EP-3946629-A1 | THERAPEUTIC TARGETS FOR ONCOGENIC KRAS-DEPENDENT CANCERS | University Of Massachusetts (US) | 2022-02-09 | — | — | EP | claimed |
| WO-2020198488-A1 | THERAPEUTIC TARGETS FOR ONCOGENIC KRAS-DEPENDENT CANCERS | UNIVERSITY OF MASSACHUSETTS (US) | 2020-10-01 | — | — | WO | claimed |
| CN-108658869-A | Compound with anti-tumor activity and preparation method thereof and the purposes in pharmacy | 复旦大学 | 2018-10-16 | — | — | CN | claimed |
| EP-3329775-A1 | PROCESSES FOR THE SYNTHESIS OF DIARYLTHIOHYDANTOIN AND DIARYLHYDANTOIN COMPOUNDS | Medivation Prostate Therapeutics LLC (US) | 2018-06-06 | — | — | EP | claimed |
| US-9174943-B2 | Processes for the synthesis of diarylthiohydantoin and diarylhydantoin compounds | MEDIVATION PROSTATE THERAPEUTICS, INC. (US) | 2015-11-03 | — | — | US | claimed |
| CN-103108549-B | Method for synthesizing diarylthiohydantoin and diarylhydantoin compounds | MEDIVATION PROSTATE THERAPEUTICS, INC. (US) | 2015-09-09 | — | — | CN | claimed |
| WO-2015042170-A1 | COMPOSITIONS AND USES OF COMBINATIONS OF DIM-RELATED INDOLES AND SELECTED ANTI-ANDROGEN COMPOUNDS | WAYNE STATE UNIVERSITY (US) | 2015-03-26 | — | — | WO | claimed |
| CN-104341396-A | Diaryl hydantoin derivative, as well as preparation method, medicine composition and application thereof | SHANGHAI PHARMACEUTICALS HOLDING CO LTD | 2015-02-11 | — | — | CN | claimed |
| EP-2646553-A1 | COMPOSITIONS AND METHODS FOR TREATING ANDROGEN RECEPTOR DEPENDENT DISORDERS INCLUDING CANCERS | Santaris Pharma A/S (DK) | 2013-10-09 | — | — | EP | claimed |
| US-20130190507-A1 | PROCESSES FOR THE SYNTHESIS OF DIARYLTHIOHYDANTOIN AND DIARYLHYDANTOIN COMPOUNDS | MEDIVATION PROSTATE THERAPEUTICS LLC | 2013-07-25 | — | — | US | claimed |
| CN-103108549-A | Method for synthesizing diarylthiohydantoin and diarylhydantoin compounds | MEDIVATION PROSTATE THERAPEUTICS INC | 2013-05-15 | — | — | CN | claimed |
| EP-2538785-A1 | PROCESSES FOR THE SYNTHESIS OF DIARYLTHIOHYDANTOIN AND DIARYLHYDANTOIN COMPOUNDS | Medivation Prostate Therapeutics, Inc. (US) | 2013-01-02 | — | — | EP | claimed |
| WO-2012065051-A1 | COMPOSITIONS AND METHODS FOR TREATING ANDROGEN RECEPTOR DEPENDENT DISORDERS INCLUDING CANCERS | ENZON PHARMACEUTICALS, INC. (US) | 2012-05-18 | — | — | WO | claimed |
| WO-2011106570-A1 | PROCESSES FOR THE SYNTHESIS OF DIARYLTHIOHYDANTOIN AND DIARYLHYDANTOIN COMPOUNDS | MEDIVATION PROSTATE THERAPEUTICS, INC. (US) | 2011-09-01 | — | — | WO | claimed |
| US-20240197701-A1 | ANDROGEN RECEPTOR INHIBITION TO TREAT SEPSIS AND SHOCK | APPLIED BIOLOGY, INC. | 2024-06-20 | — | — | US | disclosed |
| US-20240197701-A1 | ANDROGEN RECEPTOR INHIBITION TO TREAT SEPSIS AND SHOCK | APPLIED BIOLOGY, INC. | 2024-06-20 | — | — | US | disclosed |
| WO-2006124118-A1 | DIARYLHYDANTOIN COMPOUNDS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2006-11-23 | — | — | WO | disclosed |
| EP-0383092-A2 | Chromogenic merocyanine enzyme substrates | Bayer Corporation (US) | 1990-08-22 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130190507-A1 | PROCESSES FOR THE SYNTHESIS OF DIARYLTHIOHYDANTOIN AND DIARYLHYDANTOIN COMPOUNDS | BPHL, PTMS, DHPS | GBA1 4309/4885TSHR 3067/4885HIF1A 1603/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.