Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.54 |
| ▸ | RAB9A | P51151 | 3/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.54 |
| ▸ | TSHR | P16473 | 3/20 | 0.54 |
| ▸ | NPC1 | O15118 | 2/20 | 0.54 |
| ▸ | HPGD | P15428 | 2/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.54 |
| ▸ | TP53 | P04637 | 1/20 | 0.54 |
| ▸ | GLA | P06280 | 1/20 | 0.54 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.47 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29394630 | 0.83 | ALDH1A1 (0.71) | ALDH1A1HSD17B10TDP1RAB9AMAPK1 | |
| SCHEMBL445585 | 0.83 | ALDH1A1 (0.71) | ALDH1A1HSD17B10TDP1RAB9AMAPK1 | |
| SCHEMBL21367571 | 0.81 | TDP1 (0.70) | ALDH1A1HSD17B10TDP1MAPK1L3MBTL1 | |
| SCHEMBL2704242 | 0.80 | ALDH1A1 (0.53) | ALDH1A1TDP1RAB9AMAPK1L3MBTL1 | |
| SCHEMBL13595553 | 0.80 | CES2 (0.55) | ALDH1A1TDP1RAB9AMAPK1L3MBTL1 | |
| SCHEMBL25552709 | 0.79 | ALDH1A1 (0.50) | ALDH1A1TDP1MAPK1L3MBTL1TSHR | |
| SCHEMBL2171004 | 0.78 | ALDH1A1 (0.59) | ALDH1A1TDP1MAPK1L3MBTL1SMN1; SMN2 | |
| SCHEMBL27144 | 0.78 | ALDH1A1 (0.68) | ALDH1A1TDP1RAB9AMAPK1L3MBTL1 | |
| SCHEMBL7638383 | 0.78 | NR4A1 (0.51) | ALDH1A1TDP1MAPK1L3MBTL1NPC1 | |
| SCHEMBL20664990 | 0.77 | TDP1 (0.60) | ALDH1A1TDP1RAB9AMAPK1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10703745-B2 | Acyl phosphonamidates and acyl benzylamines that are Bcl family antagonists for use in clinical management of conditions caused or mediated by senescent cells and for treating cancer | UNITY BIOTECHNOLOGY, INC. (US) | 2020-07-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10703745-B2 | Acyl phosphonamidates and acyl benzylamines that are Bcl family antagonists for use in clinical management of conditions caused or mediated by senescent cells and for treating cancer | BAX, BCL2, BCOR | ALDH1A1 4045/4885HSD17B10 3727/4885TDP1 982/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.