Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.39 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.34 |
| ▸ | ALOX5AP | P20292 | 2/20 | 0.34 |
| ▸ | FEN1 | P39748 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 2/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28392372 | 0.74 | ALOX5 (0.35) | ALOX5ALOX5APFEN1 | |
| SCHEMBL20400046 | 0.73 | NLRP3 (0.39) | NLRP3ALOX5ALOX5APFEN1 | |
| SCHEMBL20939381 | 0.72 | NLRP3 (0.42) | NLRP3ALOX5ALOX5APFEN1 | |
| SCHEMBL22193802 | 0.70 | NLRP3 (0.36) | NLRP3ALOX5ALOX5APFEN1POLB | |
| SCHEMBL18209681 | 0.70 | ALOX5 (0.48) | NLRP3ALOX5ALOX5APFEN1POLB | |
| SCHEMBL20400392 | 0.69 | NLRP3 (0.48) | NLRP3ALOX5ALOX5APFEN1 | |
| SCHEMBL28975895 | 0.69 | ALDH1A1 (0.33) | POLB | |
| SCHEMBL24978765 | 0.68 | NLRP3 (0.37) | NLRP3ALOX5ALOX5APFEN1 | |
| SCHEMBL22021007 | 0.68 | NLRP3 (0.40) | NLRP3ALOX5ALOX5APFEN1 | |
| SCHEMBL20828220 | 0.68 | ALOX5 (0.41) | NLRP3ALOX5ALOX5APFEN1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107646036-B | Pyrazole derivatives useful as inhibitors of 5-lipoxygenase activating protein (FLAP) | 阿斯利康(瑞典)有限公司 | 2020-05-19 | — | — | CN | disclosed |