Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.30 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.30 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.30 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.30 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.30 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20069102 | 0.83 | CYP2D6 (0.33) | CYP2D6DGAT1HDAC3HDAC1HDAC2 | |
| SCHEMBL7826803 | 0.82 | DGAT1 (0.34) | LMNACYP2D6KDM4EDGAT1HDAC3 | |
| SCHEMBL11395424 | 0.81 | TSHR (0.39) | LMNAKDM4E | |
| SCHEMBL23745157 | 0.79 | MTNR1A (0.33) | CYP2D6DGAT1HDAC3HDAC1HDAC2 | |
| SCHEMBL1951896 | 0.78 | KDM4E (0.52) | CYP2D6KDM4EDGAT1HDAC3HDAC1 | |
| SCHEMBL31238586 | 0.78 | HDAC3 (0.37) | LMNACYP2D6DGAT1HDAC3HDAC1 | |
| SCHEMBL26000369 | 0.78 | CYP2D6 (0.32) | CYP2D6 | |
| SCHEMBL5856956 | 0.77 | MAOA (0.35) | CYP2D6KDM4EDGAT1HDAC3HDAC1 | |
| SCHEMBL16744314 | 0.76 | DGAT1 (0.33) | CYP2D6DGAT1HDAC3HDAC1HDAC2 | |
| SCHEMBL28832570 | 0.76 | DGAT1 (0.33) | LMNACYP2D6DGAT1HDAC3HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020142228-A1 | ANDROGEN RECEPTOR PROTEIN DEGRADERS | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2020-07-09 | — | — | WO | disclosed |