Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.61 |
| ▸ | MAPT | P10636 | 6/20 | 0.61 |
| ▸ | MEN1 | O00255 | 6/20 | 0.61 |
| ▸ | NPC1 | O15118 | 4/20 | 0.61 |
| ▸ | RAB9A | P51151 | 4/20 | 0.61 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.61 |
| ▸ | GLA | P06280 | 1/20 | 0.61 |
| ▸ | RELA | Q04206 | 1/20 | 0.55 |
| ▸ | GRIN2D | O15399 | 2/20 | 0.54 |
| ▸ | GRIN3B | O60391 | 2/20 | 0.54 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.54 |
| ▸ | GRIN2A | Q12879 | 2/20 | 0.54 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.54 |
| ▸ | GRIN2C | Q14957 | 2/20 | 0.54 |
| ▸ | GRIN3A | Q8TCU5 | 2/20 | 0.54 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.54 |
| ▸ | G6PC1 | P35575 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22198159 | 0.90 | ALDH1A1 (0.67) | ALDH1A1KMT2ASMN1; SMN2MAPTMEN1 | |
| SCHEMBL11123647 | 0.90 | ALDH1A1 (0.67) | ALDH1A1KMT2ASMN1; SMN2MAPTMEN1 | |
| SCHEMBL22198151 | 0.90 | L3MBTL1 (0.61) | ALDH1A1KMT2ASMN1; SMN2MAPTMEN1 | |
| SCHEMBL10909091 | 0.86 | GRIN2D (0.68) | ALDH1A1KMT2ASMN1; SMN2MAPTMEN1 | |
| SCHEMBL22198126 | 0.86 | GRIN2D (0.68) | ALDH1A1KMT2ASMN1; SMN2MAPTMEN1 | |
| SCHEMBL14423833 | 0.85 | KMT2A (0.50) | ALDH1A1KMT2ASMN1; SMN2MAPTMEN1 | |
| SCHEMBL279222 | 0.82 | ALDH1A1 (0.61) | ALDH1A1KMT2ASMN1; SMN2MAPTMEN1 | |
| SCHEMBL21173563 | 0.82 | ALDH1A1 (0.61) | ALDH1A1KMT2ASMN1; SMN2MAPTMEN1 | |
| SCHEMBL22198313 | 0.81 | KMT2A (0.47) | ALDH1A1KMT2ASMN1; SMN2MAPTMEN1 | |
| SCHEMBL22198164 | 0.81 | ALDH1A1 (0.56) | ALDH1A1KMT2ASMN1; SMN2MAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210393810-A1 | DIHYDRAZONE COMPOUNDS HAVING HIGH AFFINITY TO A BETA PROTEIN AND TAU PROTEIN, DERIVATIVES THEREOF AND USE THEREOF | HTA Co., Ltd. (CN) | 2021-12-23 | — | — | US | disclosed |
| WO-2020140924-A1 | DIHYDRAZONE COMPOUNDS HAVING HIGH AFFINITY TO AΒ PROTEIN AND TAU PROTEIN, DERIVATIVES THEREOF AND USE THEREOF | 原子高科股份有限公司 | 2020-07-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210393810-A1 | DIHYDRAZONE COMPOUNDS HAVING HIGH AFFINITY TO A BETA PROTEIN AND TAU PROTEIN, DERIVATIVES THEREOF AND USE THEREOF | MAPT, APP, PSEN1 | ALDH1A1 1343/4885KMT2A 4397/4885SMN1; SMN2 2538/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.