Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | GFER | P55789 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.41 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | PARP1 | P09874 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | MAOA | P21397 | 1/20 | 0.35 |
| ▸ | MAOB | P27338 | 1/20 | 0.35 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | KDM4A | O75164 | 1/20 | 0.34 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.34 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.34 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15617846 | 0.79 | KDM4E (0.45) | KDM4ELMNAGFERALDH1A1PRMT5 | |
| SCHEMBL22198891 | 0.73 | KDM4E (0.47) | KDM4ELMNAGFERALDH1A1L3MBTL1 | |
| SCHEMBL25747951 | 0.70 | CYP1A2 (0.47) | KDM4ELMNAGFERPRMT5WDR77 | |
| SCHEMBL28110758 | 0.69 | KDM4E (0.48) | KDM4ELMNAGFERALDH1A1PRMT5 | |
| SCHEMBL23087948 | 0.69 | PRMT5 (0.66) | KDM4ELMNAPRMT5WDR77PARP1 | |
| SCHEMBL25233016 | 0.68 | CYP1A2 (0.61) | KDM4ELMNAGFERALDH1A1PRMT5 | |
| SCHEMBL30424275 | 0.68 | CYP1A2 (0.61) | KDM4ELMNAGFERALDH1A1PRMT5 | |
| SCHEMBL22198952 | 0.68 | KDM4E (0.35) | KDM4ELMNAGFERPRMT5WDR77 | |
| SCHEMBL6558971 | 0.68 | KDM4E (0.44) | KDM4ELMNAGFERALDH1A1PRMT5 | |
| SCHEMBL22892718 | 0.67 | KDM4E (0.34) | KDM4ELMNAGFERPRMT5WDR77 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3763693-A1 | MACROCYCLE AND COMPOSITION COMPRISING THEREOF | Shenzhen TargetRx, Inc. (CN) | 2021-01-13 | — | — | EP | disclosed |
| EP-3415518-B1 | MACROCYCLE AND COMPOSITION COMPRISING THEREOF | SHENZHEN TARGETRX INC (CN) | 2020-07-08 | — | — | EP | disclosed |