Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | PRMT5 | O14744 | 8/20 | 0.33 |
| ▸ | WDR77 | Q9BQA1 | 8/20 | 0.33 |
| ▸ | GFER | P55789 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22892718 | 0.91 | KDM4E (0.34) | KDM4ELMNAPRMT5WDR77GFER | |
| SCHEMBL15617846 | 0.89 | KDM4E (0.45) | KDM4ELMNAPRMT5WDR77GFER | |
| SCHEMBL22198893 | 0.76 | KDM4E (0.32) | KDM4ELMNAPRMT5WDR77 | |
| SCHEMBL28779757 | 0.70 | PARP1 (0.31) | — | |
| SCHEMBL22198948 | 0.68 | KDM4E (0.48) | KDM4ELMNAPRMT5WDR77GFER | |
| SCHEMBL22198947 | 0.68 | CACNA1G (0.35) | — | |
| SCHEMBL5152697 | 0.66 | SMN1; SMN2 (0.44) | KDM4ELMNA | |
| SCHEMBL8200759 | 0.63 | MAPKAPK2 (0.38) | KDM4ELMNAPRMT5WDR77 | |
| SCHEMBL8404812 | 0.63 | EPHX1 (0.38) | KDM4E | |
| SCHEMBL3342222 | 0.63 | TDP1 (0.46) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3415518-B1 | MACROCYCLE AND COMPOSITION COMPRISING THEREOF | SHENZHEN TARGETRX INC (CN) | 2020-07-08 | — | — | EP | disclosed |