Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | CACNA2D1 | P54289 | 3/20 | 0.33 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.33 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | CDC25B | P30305 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2220930 | 0.93 | MEN1 (0.38) | MEN1KMT2ASMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL2221099 | 0.88 | TP53 (0.38) | MEN1KMT2ASMN1; SMN2ALDH1A1HTT | |
| SCHEMBL2221341 | 0.87 | PDE10A (0.33) | MEN1KMT2AALDH1A1HTTCACNA2D1 | |
| SCHEMBL2222006 | 0.87 | GRM2 (0.40) | MEN1KMT2ASMN1; SMN2MAPTHTT | |
| SCHEMBL2220317 | 0.86 | GRM5 (0.38) | MEN1KMT2APOLBCACNA2D1 | |
| SCHEMBL2223717 | 0.86 | KMT2A (0.33) | MEN1KMT2AALDH1A1HTTCACNA2D1 | |
| SCHEMBL2223741 | 0.85 | PDE10A (0.34) | MEN1KMT2AALDH1A1HTTCACNA2D1 | |
| SCHEMBL2268157 | 0.84 | TP53 (0.36) | MEN1KMT2AALDH1A1MAPTHTT | |
| SCHEMBL2221804 | 0.84 | ENPP2 (0.35) | MEN1KMT2AALDH1A1HTTCACNA2D1 | |
| SCHEMBL2220117 | 0.83 | CYP2C9 (0.41) | MEN1KMT2AALDH1A1HTTPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011084402-A1 | TYROSINE KINASE INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2011-07-14 | — | — | WO | disclosed |