Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 5/20 | 0.40 |
| ▸ | TP53 | P04637 | 4/20 | 0.40 |
| ▸ | CACNA2D1 | P54289 | 3/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2221099 | 0.90 | TP53 (0.38) | GRM2TP53CACNA2D1GAATSHR | |
| SCHEMBL2220196 | 0.88 | ELOVL1 (0.37) | GRM2TP53 | |
| SCHEMBL2219994 | 0.87 | MEN1 (0.37) | CACNA2D1MEN1KMT2AHTTSMN1; SMN2 | |
| SCHEMBL2223717 | 0.86 | KMT2A (0.33) | TP53CACNA2D1MEN1KMT2AHTT | |
| SCHEMBL2221804 | 0.85 | ENPP2 (0.35) | GRM2TP53CACNA2D1MEN1KMT2A | |
| SCHEMBL2223741 | 0.85 | PDE10A (0.34) | TP53CACNA2D1MEN1KMT2AHTT | |
| SCHEMBL2221216 | 0.85 | OXTR (0.35) | GRM2TP53GAAMEN1KMT2A | |
| SCHEMBL2220317 | 0.85 | GRM5 (0.38) | GRM2CACNA2D1MEN1KMT2A | |
| SCHEMBL2221341 | 0.84 | PDE10A (0.33) | TP53CACNA2D1MEN1KMT2AHTT | |
| SCHEMBL2220117 | 0.83 | CYP2C9 (0.41) | TP53CACNA2D1GAATSHRMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011084402-A1 | TYROSINE KINASE INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2011-07-14 | — | — | WO | claimed |