Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
| ▸ | LTB4R2 | Q9NPC1 | 3/20 | 0.32 |
| ▸ | CACNA2D1 | P54289 | 2/20 | 0.32 |
| ▸ | TP53 | P04637 | 2/20 | 0.32 |
| ▸ | ACHE | P22303 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 2/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | JAK2 | O60674 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.31 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.31 |
| ▸ | KLKB1 | P03952 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2220259 | 0.92 | TP53 (0.36) | KMT2AMEN1PDE10ATP53RAB9A | |
| SCHEMBL2223741 | 0.92 | PDE10A (0.34) | KMT2AMEN1PDE10ATHRBCACNA2D1 | |
| SCHEMBL2220196 | 0.91 | ELOVL1 (0.37) | THRBTP53 | |
| SCHEMBL13275659 | 0.90 | KDM4E (0.34) | KMT2AMEN1PDE10ACACNA2D1RAB9A | |
| SCHEMBL2221341 | 0.90 | PDE10A (0.33) | KMT2AMEN1PDE10ACACNA2D1TP53 | |
| SCHEMBL2271255 | 0.90 | PDE10A (0.33) | KMT2AMEN1PDE10ALTB4R2CACNA2D1 | |
| SCHEMBL2221099 | 0.89 | TP53 (0.38) | KMT2AMEN1CACNA2D1TP53RAB9A | |
| SCHEMBL13507151 | 0.88 | KMT2A (0.33) | KMT2AMEN1PDE10ACACNA2D1RAB9A | |
| SCHEMBL13275023 | 0.87 | KDM4E (0.32) | KMT2AMEN1PDE10AKDM4EL3MBTL1 | |
| SCHEMBL2362163 | 0.87 | OPRM1 (0.36) | CACNA2D1ACHEALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011084402-A1 | TYROSINE KINASE INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2011-07-14 | — | — | WO | disclosed |