Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
| ▸ | HPGD | P15428 | 3/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.43 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.43 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.42 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.42 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | TTR | P02766 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12370675 | 0.82 | IDO1 (0.50) | KDM4EHPGDSMN1; SMN2L3MBTL1MEN1 | |
| SCHEMBL905352 | 0.80 | TTR (0.51) | KDM4EHPGDSMN1; SMN2L3MBTL1MEN1 | |
| SCHEMBL365584 | 0.80 | LMNA (0.51) | KDM4EHPGDSMN1; SMN2L3MBTL1MEN1 | |
| SCHEMBL6076875 | 0.80 | ALDH1A1 (0.50) | KDM4EHPGDSMN1; SMN2L3MBTL1MEN1 | |
| SCHEMBL1196055 | 0.78 | KDM4E (0.47) | KDM4EHPGDSMN1; SMN2L3MBTL1MEN1 | |
| SCHEMBL28091557 | 0.78 | NLRP3 (0.47) | KDM4EHPGDSMN1; SMN2L3MBTL1MEN1 | |
| SCHEMBL712489 | 0.78 | MAPT (0.57) | KDM4EHPGDSMN1; SMN2L3MBTL1MEN1 | |
| SCHEMBL10401199 | 0.78 | KDM4E (0.47) | KDM4EHPGDSMN1; SMN2L3MBTL1MEN1 | |
| SCHEMBL27996454 | 0.78 | KDM4E (0.47) | KDM4EHPGDSMN1; SMN2L3MBTL1MEN1 | |
| SCHEMBL3028416 | 0.78 | MEN1 (0.49) | KDM4EHPGDSMN1; SMN2L3MBTL1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020142612-A1 | PYRIDO-PYRIMIDINONE AND PTERIDINONE COMPOUNDS AS INHIBITORS OF ENDORIBONUCLEASE INOSITOL REQUIRING ENZYME I (IRE I ALPHA) FOR THE TREATMENT OF CANCER DISEASES. | GENENTECH, INC. (US) | 2020-07-09 | — | — | WO | disclosed |