Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 9/20 | 0.35 |
| ▸ | RORC | P51449 | 3/20 | 0.35 |
| ▸ | PIK3CA | P42336 | 5/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22200825 | 0.84 | CYP1A2 (0.36) | MTORRORC | |
| SCHEMBL25034224 | 0.84 | RORC (0.38) | MTORRORCPIK3CA | |
| SCHEMBL22200393 | 0.81 | RORC (0.34) | MTORRORCPIK3CA | |
| SCHEMBL22200653 | 0.80 | MTOR (0.38) | MTORRORCPIK3CA | |
| SCHEMBL22200817 | 0.80 | MTOR (0.40) | MTORRORCPIK3CA | |
| SCHEMBL22200574 | 0.79 | ERN1 (0.34) | MTORRORC | |
| SCHEMBL22200719 | 0.79 | ERN1 (0.42) | MTORRORCPIK3CA | |
| SCHEMBL22200355 | 0.79 | ERN1 (0.41) | MTORRORCPIK3CA | |
| SCHEMBL22200424 | 0.78 | MTOR (0.37) | MTORRORCPIK3CA | |
| SCHEMBL22200818 | 0.78 | MTOR (0.36) | MTORRORCPIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020142612-A1 | PYRIDO-PYRIMIDINONE AND PTERIDINONE COMPOUNDS AS INHIBITORS OF ENDORIBONUCLEASE INOSITOL REQUIRING ENZYME I (IRE I ALPHA) FOR THE TREATMENT OF CANCER DISEASES. | GENENTECH, INC. (US) | 2020-07-09 | — | — | WO | disclosed |