SCHEMBL22201222

SCHEMBL22201222

N=C(CCCc1ccc2ccccc2c1)OC(=O)O

nearest known ligand 0.66

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 2/20 0.66
CYP2D6 P10635 1/20 0.54
CYP2C19 P33261 1/20 0.54
HDAC1 Q13547 2/20 0.51
HDAC8 Q9BY41 1/20 0.51
HCAR2 Q8TDS4 2/20 0.47
PDPK1 O15530 1/20 0.47
SIGMAR1 Q99720 2/20 0.44
SLC13A5 Q86YT5 1/20 0.44
NAAA Q02083 1/20 0.43
FFAR1 O14842 1/20 0.43
SOX18 P35713 1/20 0.43
HDAC3 O15379 1/20 0.41
HDAC2 Q92769 1/20 0.41
HDAC6 Q9UBN7 1/20 0.41
PLAU P00749 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21149844 0.83 HDAC1 (0.58) HDAC1HDAC8FFAR1HDAC3HDAC2
SCHEMBL30061865 0.80 CYP1A2 (1.00) CYP1A2CYP2D6CYP2C19HDAC1HDAC8
SCHEMBL2318140 0.80 CYP1A2 (1.00) CYP1A2CYP2D6CYP2C19HDAC1HDAC8
SCHEMBL22201278 0.79 MAPT (0.58) HDAC1HDAC8FFAR1HDAC3HDAC2
SCHEMBL22201127 0.77 MAPT (0.61) HDAC1HDAC8HDAC3HDAC2HDAC6
SCHEMBL22201233 0.77 TAAR1 (0.46) HDAC1HDAC8HCAR2FFAR1HDAC3
SCHEMBL1285452 0.77 CYP1A2 (0.75) CYP1A2CYP2D6CYP2C19HDAC1HDAC8
SCHEMBL27862045 0.77 CYP1A2 (0.69) CYP1A2CYP2D6CYP2C19HDAC1HDAC8
SCHEMBL21148532 0.77 ALOX5 (0.57) CYP1A2CYP2D6CYP2C19FFAR1
SCHEMBL22201167 0.76 HDAC3 (0.47) HDAC1HDAC8PDPK1FFAR1HDAC3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2020141734-A1 METHOD FOR PREPARING CHIRAL GAMMA-LACTAM COMPOUND AND METAL COMPLEX THEREFOR 기초과학연구원 2020-07-09 WO disclosed