Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 10/20 | 0.56 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.49 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.49 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.49 |
| ▸ | SYK | P43405 | 1/20 | 0.48 |
| ▸ | BTK | Q06187 | 1/20 | 0.48 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.48 |
| ▸ | HTR2A | P28223 | 1/20 | 0.47 |
| ▸ | HTR2C | P28335 | 1/20 | 0.47 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.46 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.46 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.46 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.46 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.46 |
| ▸ | PLK4 | O00444 | 1/20 | 0.45 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22201290 | 0.82 | PIK3CA (0.65) | PIK3CAPIK3CDPIK3CBPIK3CGROCK2 | |
| SCHEMBL27595864 | 0.77 | PIK3CA (0.47) | PIK3CAPIK3CDPIK3CBPIK3CGROCK2 | |
| SCHEMBL3580875 | 0.77 | ROCK2 (0.53) | PIK3CAROCK2GRM4TGFBR1ROCK1 | |
| SCHEMBL2469890 | 0.73 | PIK3CA (0.58) | PIK3CAPIK3CDPIK3CBPIK3CGROCK2 | |
| SCHEMBL22201268 | 0.72 | TGFBR1 (0.51) | PIK3CAROCK2MKNK1GRM4TGFBR1 | |
| SCHEMBL1821372 | 0.71 | PIK3CA (1.00) | PIK3CAPIK3CDPIK3CBPIK3CGROCK2 | |
| SCHEMBL1822731 | 0.71 | PIK3CA (0.63) | PIK3CAPIK3CDPIK3CBPIK3CGROCK2 | |
| SCHEMBL1311233 | 0.71 | GRIA1 (0.52) | PIK3CAPIK3CDPIK3CGROCK2ROCK1 | |
| SCHEMBL20784048 | 0.71 | ROCK2 (0.78) | PIK3CAROCK2ROCK1 | |
| SCHEMBL22201371 | 0.71 | ROCK2 (0.68) | ROCK2HTR2ATGFBR1ROCK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020142748-A1 | METHODS AND MATERIALS FOR INCREASING TRANSCRIPTION FACTOR EB POLYPEPTIDE LEVELS | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2020-07-09 | — | — | WO | disclosed |