Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 4/20 | 0.44 |
| ▸ | P2RX3 | P56373 | 5/20 | 0.37 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | UBE2M | P61081 | 2/20 | 0.35 |
| ▸ | DCUN1D1 | Q96GG9 | 2/20 | 0.35 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.34 |
| ▸ | KDR | P35968 | 2/20 | 0.34 |
| ▸ | EPHB4 | P54760 | 2/20 | 0.34 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.34 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.34 |
| ▸ | EGFR | P00533 | 1/20 | 0.33 |
| ▸ | IGF1R | P08069 | 1/20 | 0.33 |
| ▸ | SRC | P12931 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22201305 | 0.89 | SYK (0.44) | SYKP2RX3MEN1KMT2AUBE2M | |
| SCHEMBL22201302 | 0.89 | SYK (0.44) | SYKP2RX3MEN1KMT2AUBE2M | |
| SCHEMBL22201304 | 0.88 | SYK (0.43) | SYKP2RX3MEN1KMT2AUBE2M | |
| SCHEMBL22201292 | 0.87 | SYK (0.42) | SYKUBE2MDCUN1D1TP53KDR | |
| SCHEMBL22201245 | 0.87 | SYK (0.42) | SYKP2RX3MEN1KMT2ASLC2A1 | |
| SCHEMBL22201404 | 0.86 | P2RX3 (0.38) | P2RX3ADORA3MEN1KMT2AKDR | |
| SCHEMBL22201368 | 0.86 | SYK (0.45) | SYKP2RX3ADORA3MEN1KMT2A | |
| SCHEMBL22201306 | 0.85 | SYK (0.41) | SYKP2RX3KMT2AUBE2MDCUN1D1 | |
| SCHEMBL22201288 | 0.85 | ABL1 (0.39) | P2RX3MEN1KMT2AALDH1A1KDR | |
| SCHEMBL22201286 | 0.81 | P2RX3 (0.40) | SYKP2RX3ADORA3TP53ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020142748-A1 | METHODS AND MATERIALS FOR INCREASING TRANSCRIPTION FACTOR EB POLYPEPTIDE LEVELS | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2020-07-09 | — | — | WO | disclosed |