Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 3/20 | 0.41 |
| ▸ | METAP1 | P53582 | 1/20 | 0.39 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.38 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.38 |
| ▸ | CDC42BPB | Q9Y5S2 | 3/20 | 0.38 |
| ▸ | ALOX12 | P18054 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | HCRTR1 | O43613 | 2/20 | 0.34 |
| ▸ | BACE1 | P56817 | 1/20 | 0.34 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | UBE2M | P61081 | 1/20 | 0.33 |
| ▸ | DCUN1D1 | Q96GG9 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22201403 | 0.87 | ROCK2 (0.35) | ROCK2ROCK1CDC42BPBALOX12ALDH1A1 | |
| SCHEMBL22201522 | 0.86 | ROCK2 (0.39) | ROCK2ROCK1CDC42BPBALDH1A1HCRTR1 | |
| SCHEMBL22201305 | 0.85 | SYK (0.44) | SYKROCK2ALOX12ALDH1A1SMN1; SMN2 | |
| SCHEMBL22201302 | 0.85 | SYK (0.44) | SYKROCK2ALOX12ALDH1A1SMN1; SMN2 | |
| SCHEMBL22201293 | 0.85 | SYK (0.44) | SYKROCK2ALOX12ALDH1A1P2RX3 | |
| SCHEMBL22201304 | 0.84 | SYK (0.43) | SYKROCK2ALOX12ALDH1A1SMN1; SMN2 | |
| SCHEMBL22201292 | 0.83 | SYK (0.42) | SYKSMN1; SMN2LMNAGAAUBE2M | |
| SCHEMBL22201245 | 0.83 | SYK (0.42) | SYKROCK2ALOX12ALDH1A1SMN1; SMN2 | |
| SCHEMBL22201368 | 0.82 | SYK (0.45) | SYKALOX12ALDH1A1P2RX3KMT2A | |
| SCHEMBL22201519 | 0.80 | SYK (0.40) | SYKALOX12ALDH1A1SMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020142748-A1 | METHODS AND MATERIALS FOR INCREASING TRANSCRIPTION FACTOR EB POLYPEPTIDE LEVELS | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2020-07-09 | — | — | WO | disclosed |