Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 11/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 7/20 | 0.50 |
| ▸ | HPGD | P15428 | 7/20 | 0.50 |
| ▸ | POLB | P06746 | 6/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.50 |
| ▸ | RAB9A | P51151 | 5/20 | 0.49 |
| ▸ | NPC1 | O15118 | 4/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 9/20 | 0.48 |
| ▸ | TSHR | P16473 | 3/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 2/20 | 0.47 |
| ▸ | USP2 | O75604 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22201384 | 0.93 | PRKCH (0.51) | KDM4EALDH1A1HSD17B10HPGDPOLB | |
| SCHEMBL22201386 | 0.92 | ALDH1A1 (0.51) | KDM4EALDH1A1HSD17B10HPGDPOLB | |
| SCHEMBL30402182 | 0.80 | KDM4E (0.63) | KDM4EALDH1A1HSD17B10HPGDPOLB | |
| SCHEMBL17544089 | 0.80 | KDM4E (0.63) | KDM4EALDH1A1HSD17B10HPGDPOLB | |
| SCHEMBL22201379 | 0.80 | NPC1 (0.50) | KDM4EALDH1A1HSD17B10HPGDNPSR1 | |
| SCHEMBL22201452 | 0.79 | PRKCH (0.58) | KDM4EALDH1A1HPGDPOLBSMN1; SMN2 | |
| SCHEMBL22201637 | 0.76 | PRKCH (0.50) | KDM4EALDH1A1HPGDCYP1A2CYP2C19 | |
| SCHEMBL30402998 | 0.75 | KDM4E (0.57) | KDM4EALDH1A1HSD17B10HPGDPOLB | |
| SCHEMBL17544343 | 0.75 | KDM4E (0.57) | KDM4EALDH1A1HSD17B10HPGDPOLB | |
| SCHEMBL22201642 | 0.74 | PRKCH (0.53) | KDM4EALDH1A1HPGDPOLBSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020142748-A1 | METHODS AND MATERIALS FOR INCREASING TRANSCRIPTION FACTOR EB POLYPEPTIDE LEVELS | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2020-07-09 | — | — | WO | disclosed |