Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 2/20 | 0.46 |
| ▸ | ULK1 | O75385 | 5/20 | 0.40 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.40 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.39 |
| ▸ | OGG1 | O15527 | 1/20 | 0.37 |
| ▸ | HTR2A | P28223 | 3/20 | 0.36 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.35 |
| ▸ | LPAR2 | Q9HBW0 | 1/20 | 0.35 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.35 |
| ▸ | ULK2 | Q8IYT8 | 1/20 | 0.35 |
| ▸ | PAK4 | O96013 | 2/20 | 0.35 |
| ▸ | AXL | P30530 | 1/20 | 0.35 |
| ▸ | GSK3A | P49840 | 1/20 | 0.35 |
| ▸ | GSK3B | P49841 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22201378 | 0.78 | ROCK2 (0.62) | PDE5AULK1ROCK2TGFBR1PAK4 | |
| SCHEMBL3575009 | 0.72 | GRM4 (0.45) | PDE5AGRM4TGFBR1 | |
| SCHEMBL13316097 | 0.72 | ABCG2 (0.55) | PDE5AGSK3AGSK3B | |
| SCHEMBL3582360 | 0.71 | ROCK2 (0.64) | PDE5AULK1ROCK2OGG1TGFBR1 | |
| SCHEMBL3580233 | 0.67 | ABCG2 (0.63) | PDE5A | |
| SCHEMBL16404477 | 0.65 | PDE5A (0.66) | PDE5A | |
| SCHEMBL14262834 | 0.64 | PDE5A (0.72) | PDE5AOGG1TGFBR1 | |
| SCHEMBL3347649 | 0.64 | KDM4E (0.48) | GRM4 | |
| SCHEMBL786840 | 0.63 | PDE5A (0.62) | PDE5AOGG1LPAR2GSK3AGSK3B | |
| SCHEMBL14262923 | 0.62 | PDE5A (0.82) | PDE5AOGG1TGFBR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020142748-A1 | METHODS AND MATERIALS FOR INCREASING TRANSCRIPTION FACTOR EB POLYPEPTIDE LEVELS | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2020-07-09 | — | — | WO | disclosed |