Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 16/20 | 0.51 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.47 |
| ▸ | ULK1 | O75385 | 1/20 | 0.46 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.46 |
| ▸ | CLK2 | P49760 | 1/20 | 0.45 |
| ▸ | BLK | P51451 | 1/20 | 0.45 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.45 |
| ▸ | STK3 | Q13188 | 1/20 | 0.45 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.45 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.45 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.45 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.44 |
| ▸ | IDO1 | P14902 | 1/20 | 0.43 |
| ▸ | TDO2 | P48775 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3582360 | 0.82 | ROCK2 (0.64) | ROCK2TGFBR1ULK1ROCK1CLK2 | |
| SCHEMBL22201444 | 0.80 | ROCK2 (0.55) | ROCK2TGFBR1ROCK1CLK2BLK | |
| SCHEMBL22201378 | 0.79 | ROCK2 (0.62) | ROCK2TGFBR1ULK1ROCK1 | |
| SCHEMBL13994060 | 0.78 | MKNK1 (0.48) | ROCK2CYP3A4 | |
| SCHEMBL312320 | 0.77 | ROCK2 (0.68) | ROCK2ROCK1CYP3A4 | |
| SCHEMBL1728902 | 0.77 | ROCK2 (0.64) | ROCK2ROCK1CLK2BLKCSNK2A1 | |
| SCHEMBL3793015 | 0.77 | ROCK2 (0.64) | ROCK2ROCK1CLK2BLKCSNK2A1 | |
| SCHEMBL1728904 | 0.77 | ROCK2 (0.64) | ROCK2ROCK1CLK2BLKCSNK2A1 | |
| SCHEMBL9952336 | 0.76 | FASN (0.52) | ROCK2CYP3A4IDO1TDO2 | |
| SCHEMBL14514349 | 0.74 | ROCK2 (0.63) | ROCK2ROCK1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020142748-A1 | METHODS AND MATERIALS FOR INCREASING TRANSCRIPTION FACTOR EB POLYPEPTIDE LEVELS | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2020-07-09 | — | — | WO | disclosed |