Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.72 |
| ▸ | LMNA | P02545 | 2/20 | 0.63 |
| ▸ | POLB | P06746 | 3/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.60 |
| ▸ | HPGD | P15428 | 2/20 | 0.60 |
| ▸ | PDE5A | O76074 | 2/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.60 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.56 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.56 |
| ▸ | GSK3B | P49841 | 2/20 | 0.55 |
| ▸ | GSK3A | P49840 | 1/20 | 0.55 |
| ▸ | ABCG2 | Q9UNQ0 | 7/20 | 0.54 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.54 |
| ▸ | LATS1 | O95835 | 2/20 | 0.52 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.52 |
| ▸ | AURKA | O14965 | 1/20 | 0.52 |
| ▸ | SRC | P12931 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1059917 | 0.93 | ABCG2 (0.60) | KDM4ELMNAALDH1A1PDE5ATGFBR1 | |
| SCHEMBL22201550 | 0.85 | POLB (0.58) | KDM4ELMNAPOLBALDH1A1HPGD | |
| SCHEMBL22201541 | 0.84 | KDM4E (0.72) | KDM4ELMNAPOLBALDH1A1HPGD | |
| SCHEMBL22201544 | 0.83 | KDM4E (0.70) | KDM4ELMNAPOLBALDH1A1HPGD | |
| SCHEMBL22201542 | 0.80 | KDM4E (0.65) | KDM4ELMNAPOLBALDH1A1HPGD | |
| SCHEMBL22201640 | 0.79 | PRKCH (0.52) | KDM4E | |
| SCHEMBL22201678 | 0.78 | HPGD (0.65) | KDM4ELMNAPOLBALDH1A1HPGD | |
| SCHEMBL22201341 | 0.78 | PRKD1 (0.66) | KDM4ELMNAPOLBALDH1A1HPGD | |
| SCHEMBL22201652 | 0.78 | LMNA (1.00) | KDM4ELMNAPOLBALDH1A1HPGD | |
| SCHEMBL22201483 | 0.77 | LMNA (0.83) | KDM4ELMNAPOLBALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020142748-A1 | METHODS AND MATERIALS FOR INCREASING TRANSCRIPTION FACTOR EB POLYPEPTIDE LEVELS | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2020-07-09 | — | — | WO | disclosed |