Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.65 |
| ▸ | LMNA | P02545 | 2/20 | 0.61 |
| ▸ | POLB | P06746 | 3/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.57 |
| ▸ | HPGD | P15428 | 2/20 | 0.57 |
| ▸ | PDE5A | O76074 | 2/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.57 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.54 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.54 |
| ▸ | GSK3B | P49841 | 2/20 | 0.53 |
| ▸ | GSK3A | P49840 | 1/20 | 0.53 |
| ▸ | AURKA | O14965 | 1/20 | 0.53 |
| ▸ | SRC | P12931 | 1/20 | 0.53 |
| ▸ | ABCG2 | Q9UNQ0 | 6/20 | 0.52 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.52 |
| ▸ | LATS1 | O95835 | 2/20 | 0.50 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22201544 | 0.81 | KDM4E (0.70) | KDM4ELMNAPOLBALDH1A1HPGD | |
| SCHEMBL22201545 | 0.80 | KDM4E (0.72) | KDM4ELMNAPOLBALDH1A1HPGD | |
| SCHEMBL22201483 | 0.78 | LMNA (0.83) | KDM4ELMNAPOLBALDH1A1HPGD | |
| SCHEMBL22201477 | 0.78 | HPGD (0.64) | KDM4ELMNAPOLBALDH1A1HPGD | |
| SCHEMBL22201546 | 0.76 | KDM4E (0.70) | KDM4ELMNAPOLBALDH1A1HPGD | |
| SCHEMBL22201652 | 0.76 | LMNA (1.00) | KDM4ELMNAPOLBALDH1A1HPGD | |
| SCHEMBL22201541 | 0.75 | KDM4E (0.72) | KDM4ELMNAPOLBALDH1A1HPGD | |
| SCHEMBL7434986 | 0.74 | ALDH1A1 (1.00) | KDM4ELMNAPOLBALDH1A1HPGD | |
| SCHEMBL14262837 | 0.74 | KDM4E (0.94) | KDM4ELMNAPOLBALDH1A1HPGD | |
| SCHEMBL1084045 | 0.73 | MAPT (0.85) | KDM4ELMNAPOLBALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020142748-A1 | METHODS AND MATERIALS FOR INCREASING TRANSCRIPTION FACTOR EB POLYPEPTIDE LEVELS | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2020-07-09 | — | — | WO | disclosed |