SCHEMBL2220158

SCHEMBL2220158

c1ccc2cc3cc(-c4ccc5ccccc5n4)ccc3cc2c1

nearest known ligand 0.61

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NPC1 O15118 12/20 0.61
RAB9A P51151 12/20 0.61
AR P10275 4/20 0.61
MEN1 O00255 3/20 0.61
KMT2A Q03164 3/20 0.61
ALDH1A1 P00352 10/20 0.61
KDM4E B2RXH2 9/20 0.61
SMN1; SMN2 Q16637 8/20 0.61
NFKB1 P19838 3/20 0.61
NFKB2 Q00653 3/20 0.61
RELA Q04206 3/20 0.61
MAPT P10636 7/20 0.59
HPGD P15428 5/20 0.59
HSD17B10 Q99714 4/20 0.59
TP53 P04637 3/20 0.59
PKM P14618 3/20 0.59
CYP3A4 P08684 2/20 0.59
GMNN O75496 1/20 0.59
THPO P40225 1/20 0.59
BLM P54132 1/20 0.59

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL34467584 0.94 NPC1 (0.63) NPC1RAB9AARMEN1KMT2A
SCHEMBL240431 0.94 NPC1 (0.63) NPC1RAB9AARMEN1KMT2A
SCHEMBL4337601 0.92 NPC1 (0.61) NPC1RAB9AARMEN1KMT2A
SCHEMBL21215925 0.88 ALDH1A1 (0.47) NPC1RAB9AARMEN1KMT2A
SCHEMBL21215931 0.86 CYP1A2 (0.50) NPC1RAB9AARMEN1KMT2A
SCHEMBL21215800 0.86 NPC1 (0.50) NPC1RAB9AARMEN1KMT2A
SCHEMBL14505859 0.85 NPC1 (0.58) NPC1RAB9AARMEN1KMT2A
SCHEMBL12112870 0.85 RAB9A (0.80) NPC1RAB9AARMEN1KMT2A
SCHEMBL21215612 0.85 NPC1 (0.49) NPC1RAB9AARMEN1KMT2A
SCHEMBL21215629 0.85 NPC1 (0.49) NPC1RAB9AARMEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 45 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2005010081-A1 AROMATIC MONOMER-AND CONJUGATED POLYMER-METAL COMPLEXES SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2005-02-03 WO claimed
US-20050014023-A1 Aromatic monomer- and conjugated polymer-metal complexes SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2005-01-20 US claimed
US-8071769-B2 Aromatic monomer- and conjugated polymer-metal complexes SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2011-12-06 US disclosed
US-20110172426-A1 AROMATIC MONOMER- AND CONJUGATED POLYMER-METAL COMPLEXES SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2011-07-14 US disclosed
US-20100160631-A1 AROMATIC MONOMER- AND CONJUGATED POLYMER-METAL COMPLEXES SUMITOMO CHEMICHAL COMPANY, LIMITED (JP) 2010-06-24 US disclosed
US-7718087-B2 Organic iridium compositions and their use in electronic devices GENERAL ELECTRIC COMPANY (US) 2010-05-18 US disclosed
US-7718277-B2 Electronic devices comprising organic iridium compositions GENERAL ELECTRIC COMPANY (US) 2010-05-18 US disclosed
US-7718277-B2 Electronic devices comprising organic iridium compositions GENERAL ELECTRIC COMPANY (US) 2010-05-18 US disclosed
US-7718087-B2 Organic iridium compositions and their use in electronic devices GENERAL ELECTRIC COMPANY (US) 2010-05-18 US disclosed
US-7704610-B2 organic light emitting device comprising deuterated organic iridium complex; optoelectronic devices, photovoltaic devices; enhanced color properties and light output efficiencies GENERAL ELECTRIC COMPANY (US) 2010-04-27 US disclosed
US-7705528-B2 Aromatic monomer-and conjugated polymer-metal complexes SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2010-04-27 US disclosed
US-20080023672-A1 Organic iridium compositions and their use in electronic devices GENERAL ELECTRIC COMPANY 2008-01-31 US disclosed
US-20080023672-A1 Organic iridium compositions and their use in electronic devices GENERAL ELECTRIC COMPANY 2008-01-31 US disclosed
US-20080026249-A1 Electronic devices comprising organic iridium compositions GENERAL ELECTRIC COMPANY 2008-01-31 US disclosed
US-20080026249-A1 Electronic devices comprising organic iridium compositions GENERAL ELECTRIC COMPANY 2008-01-31 US disclosed
CN-1829725-A aromatic monomer and conjugated polymer-metal complex SUMITOMO CHEMICAL CO (JP) 2006-09-06 CN disclosed
WO-2005016945-A1 AROMATIC MONOMER-AND CONJUGATED POLYMER-METAL COMPLEXES SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2005-02-24 WO disclosed
US-20050031900-A1 Aromatic monomer-and conjugated polymer-metal complexes SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2005-02-10 US disclosed
WO-2005010081-A1 AROMATIC MONOMER-AND CONJUGATED POLYMER-METAL COMPLEXES SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2005-02-03 WO disclosed
US-20050014023-A1 Aromatic monomer- and conjugated polymer-metal complexes SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2005-01-20 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100160631-A1 AROMATIC MONOMER- AND CONJUGATED POLYMER-METAL COMPLEXES DDT, TYR, DDC NPC1 4774/4885RAB9A 759/4885AR 3590/4885
US-20110172426-A1 AROMATIC MONOMER- AND CONJUGATED POLYMER-METAL COMPLEXES DDT, TYR, DDC NPC1 4774/4885RAB9A 759/4885AR 3590/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.